Septic shock. Severe sepsis with septic shock
Conditions
Interventions
Intervention 1: Intervention group: These patients are given two 100 miligram Vitamin B1 pills that each contains 100 miligram Vitamin B1 and manufactured by Daroopakhsh/Iran, twice daily for 7 days p
Sponsors
Mashhad University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Ages over 18 years old Patients with septic shock(a patient that meets the criteria for sepsis and despite adequite fluid thrapy needs vasopressor to preserve MAP = 65mmhg and serum lactate is greater than 2 mmol) Complete informed consent form in the first stage of legal guardianship and in case of failure we refer to the judge of the country Serum lactate is greater than 2 mmol/li Hypotention(systolic BP less than 90 mmhg despite adequite fluid thrapy needs vasopressor(Dopamin = 5mcg/kg/min or Phenylephrine) Refusal to participate in any other intervention research project
Exclusion criteria
Exclusion criteria: Liver failure or dysfunction(AST OR ALT >240 unit/li or known cirrhosis) based on previous findings that patients with liver dysfunction may have increased levels of thiamine. Indication of receiving thiamine(Alcohol abuse) Other causes of increased lactate levels(seizure in 3 hours) Prescription of high-levev lactate -like drugs (Linezolid-Methformine)by your phicision Cyanide or CO poisoning Known mitochondrial disease Known or suspected ischemia of the intestine or other organs
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mortality within hospitalization. Timepoint: 28-day hospital mortality rate. Method of measurement: Patient mortality rate.;Duration of hospitalization in Intensive Care Unit. Timepoint: From the begining to the end of admition in Intensive Care Unit. Method of measurement: Number of days.;Level of serum lactate. Timepoint: At 0 and 24 hours after intervention. Method of measurement: By examining blood plasma by the method of euthoanalyzer.;Level of serum thiamine. Timepoint: At 0 hours after intervention. Method of measurement: High-performance liquid Chromatography(HOLC) with normal reference range 16-48 ng/ml.;Illness severity. Timepoint: Information on the Acute physiology and cronic health evaluation (APACHE II) questionnaire is collected once a week and Sequential organ failure assessment ( SOFA) questionnaire is collected every other day. Method of measurement: By index Sequential organ failure assessment ( SOFA) and Acute physiology and cronic health evaluation (APACHE II ) questionnaire. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactZahra Ataee
Mashhad University of Medical Sciences
Outcome results
None listed