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The Efficacy of Rivastigmine Augementation to Antipsychotic Agents on Positive and Negative Symptoms and Quality of Life in Patients with Chronic Schizophrenia

The Efficacy of Rivastigmine Augementation to Antipsychotic Agents on Positive and Negative Symptoms and Quality of Life in Patients with Chronic Schizophrenia

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20190530043769N1
Enrollment
60
Registered
2021-01-26
Start date
2021-02-03
Completion date
Unknown
Last updated
2021-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic schizophrenia. Paranoid schizophrenia

Interventions

Intervention 1: Interference Group: this group includes chronic schizophrenia patients that receive Rivastigmine capsules (1.5 mg) twice daily along with the previous antipsychotic medication for eigh
at the start point, after four weeks and at the end of eight weeks, using PANSS questionnaires and life quality. Intervention 2: Control group: this group includes chronic schizophrenia patients that
at the start point, after four weeks and at the end of eight weeks, using PANSS questionnaires and life quality.

Sponsors

Tabriz University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: All patients with Chronic Schizophrenia Patients treated with Antipsychotics

Exclusion criteria

Exclusion criteria: Drug abuse IQ less than 70 ?Another psychiatric disorder Physical illness ECT in the last two weeks Sensitivity to Rivastigmine

Design outcomes

Primary

MeasureTime frame
Efficacy of Rivastigmine. Timepoint: Efficacy of Rivastigmine in three stages: at the start point, after 4 weeks and at the end of study. Method of measurement: Positive, negative symptoms questionnaire in Chronic schizophrenia patients.;Efficacy of rivastigmine. Timepoint: Efficacy of Rivastigmine in three stages: at the start point, after 4 weeks and at the end of study. Method of measurement: Quality of Life Questionnaire in Chronic schizophrenic Patients.

Secondary

MeasureTime frame
Side effect. Timepoint: Two months after starting therapy. Method of measurement: Medical history and examination.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactZahra Jahangiri

Tabriz University of Medical Sciences

za.jahangiri1986@gmail.com+98 41 3380 4486

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026