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The Effect of Laminaria with Vaginal Misoprostol on Cervical Preparation in Induction of Second Trimester Abortion

Comparison of the effect of vaginal misoprostol alone and vaginal misoprostol simultaneously with laminaria in induction of second trimester pregnancy (14-20 weeks) in patients referred to Imam Ali Hospital's Hospital (Clinical Practice)

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20190529043759N1
Enrollment
90
Registered
2019-07-07
Start date
2019-06-22
Completion date
Unknown
Last updated
2019-08-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Medical abortion. Complications following (induced) termination of pregnancy

Interventions

Intervention 1: Intervention group: Embedding of Laminaria In the cervix with 400 µg Misoprostol Vaginally every 8 hours, up to 48 hours. Intervention 2: Control group: 400 µg Misoprostol Vaginally ev

Sponsors

Zahedan University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female

Inclusion criteria

Inclusion criteria: Pregnant women between 14-20 weeks of pregnancy at Imam Ali Hospital who are candidates for termination of pregnancy due to severe anomalies or due to fetal death Singleton conditions, parity 1 to 3, painless and uterine infections

Exclusion criteria

Exclusion criteria: Allergy to the drug parity of more than three severe anemia active liver disease cardiovascular disease uncontrolled seizures having IUD Placenta Previa History of cesarean section previous incision on the uterus Use of corticosteroids Use of anti coagulants

Design outcomes

Primary

MeasureTime frame
Termination of pregnancy. Timepoint: Every eight hours to six times. Method of measurement: dilatation of cervix and contraction.

Secondary

MeasureTime frame
Need for curettage. Timepoint: From the start, every eight hours to six turns. Method of measurement: Clinical examinations.;Abortion time in labor. Timepoint: Interval between administration of drug and expulsion of fetus. Method of measurement: Record time.;Time of admission in hospital after abortion. Timepoint: From the time of the abortion to the patient's discharge. Method of measurement: Record time.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactFatemeh Behnood

Zahedan University of Medical Sciences

dr.f.behnood@zaums.ac.ir+98 54 3329 5570

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026