cirrhosis. Cirrhosis
Conditions
Interventions
Intervention 1: Intervention group: patients will receive 600 mg tablets of NAC twice a day for 6 months. Intervention 2: Control group: Patients will receive placebo tablets completely similar to NAC
Sponsors
Shahid Beheshti University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: Child suffering class A or B of cirrhosis Patients with score of 5-9 of child pugh score
Exclusion criteria
Exclusion criteria: Patient with class c of child pugh score
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Liver function. Timepoint: At the baseline and 6 months after starting N-acetylcycteine. Method of measurement: Child-Puff score system with scores categorized as A, B and C.;Liver function. Timepoint: At the baseline and 6 months after starting N-acetylcycteine. Method of measurement: MELD scoring system based on bilirubin and creatinine serum levels. | — |
Secondary
| Measure | Time frame |
|---|---|
| Kidney function. Timepoint: At the baseline and 6 months after starting N-acetylcycteine. Method of measurement: Creatinine level due to lab results.;Kidney function. Timepoint: At the baseline and 6 months after starting N-acetylcycteine. Method of measurement: Urea level due to lab results.;Liver function. Timepoint: At the baseline and 6 months after starting N-acetylcycteine. Method of measurement: Aspartate Transaminase (AST) level due to lab results.;Liver function. Timepoint: At the baseline and 6 months after starting N-acetylcycteine. Method of measurement: Alanine Aminotransferase (ALT) level due to lab results.;Liver function. Timepoint: At the baseline and 6 months after starting N-acetylcycteine. Method of measurement: Total bilirubin level due to lab results.;Liver function. Timepoint: At the baseline and 6 months after starting N-acetylcycteine. Method of measurement: Albumin level due to lab results.;Liver function. Timepoint: At the baseline and 6 months after starting N-acetylcycteine. Method of measurement: Prothrombin time (PT) level due to lab resulst.;Liver function. Timepoint: At the baseline and 6 months after starting N-acetylcycteine. Method of measurement: International Normalized Ratio (INR) level due to lab resulst.;Blood parameter. Timepoint: At the baseline and 6 months after starting N-acetylcycteine. Method of measurement: Hemoglobin level due to lab results.;Blood parameter. Timepoint: At the baseline and 6 months after starting N-acetylcycteine. Method of measurement: Platelet number due to lab results. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMaryam Masoumi
Shahid Beheshti University of Medical Sciences
Outcome results
None listed