Condition 1: Gastrointestinal bleeding. Condition 2: Ventilator-associated pneumonia. Other agents primarily affecting the gastrointestinal system Interstitial pulmonary disease, unspecified
Conditions
Interventions
Intervention 1: Intervention group 1: Who will receive 4 mg/kg/day of intravenous ranitidine 3 times per day. Intervention 2: Intervention group 2: Who will receive 1 mg/kg/day of intravenous pantopra
Sponsors
Mashhad University of Medical Sciences
Eligibility
Sex/Gender
All
Age
1 Months to 18 Years
Inclusion criteria
Inclusion criteria: The patients admitted to the pediatric care unit who have been under ventilation for at least 48 hours.
Exclusion criteria
Exclusion criteria: Hospital stay or mechanical ventilation less than 48 hours Gastrointestinal bleeding before the onset of the treatment, Ventilator-associated pneumonia before the onset of the treatment
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The rate of ventilator-associated pneumonia. Timepoint: 48 hours after intervention. Method of measurement: chest radiograghy.;The rate of gastrointestinal bleeding. Timepoint: 48 hours after intervention. Method of measurement: Blood in stool and vomit. | — |
Secondary
| Measure | Time frame |
|---|---|
| Upper airway colonization. Timepoint: 48 hours after intervention. Method of measurement: Microbiological culture.;Hospital stay in the intensive care unit. Timepoint: After intervention. Method of measurement: Questionnaire.;The rate of mortality. Timepoint: After intervention. Method of measurement: Questionnaire. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMajid Sezavar
Mashhad University of Medical Sciences
Outcome results
None listed