Comparison of the use of Epinephrine, Norepinephrine and Phenylephrine drugs during cardiopulmonary bypass on brain oxygenation

The study of the effect of the use of Epinephrine, Norepinephrine and Phenylephrine drugs during cardiopulmonary bypass on brain oxygenation in patients undergoing open heart surgery

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20190514043582N1

Enrollment

Registered

2019-06-18

Start date

2019-08-20

Completion date

Unknown

Last updated

2019-08-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

hypotension. Other hypotension

Interventions

Intervention 1: Intervention group: At the entrance to the operating room, patients will receive oxygen from the nasal cannula at 2 liters per minute. The ECG and average arterial blood pressure moni

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Patient satisfaction to participate in the study Patients undergoing elective open-heart surgery (Coronary artery bypass graft surgery and heart valve surgery) Patients older than 18 years No history of transient cerebral ischemic disease or stroke No history of narrowing of the carotid arteries by more than 70% or no clear stenosis No history of previous cardiac surgery Not having of uncontrolled diabetes (with the opinion of an internal specialist) or the absence of uncontrolled blood pressure (with the opinion of the cardiologist)

Exclusion criteria

Exclusion criteria: Heart arrest before starting cardiac bypass No need to prescribe inotropic drugs during surgery

Design outcomes

Primary

Measure	Time frame
Brain Oxygenation. Timepoint: 120, 150 and 180 seconds after injections of inotropic drugs during cardiopulmonary bypass. Method of measurement: Monitoring of cerebral oxygen saturation.;Blood lactate level. Timepoint: Before the starting of cardiopulmonary bypass and during anesthesia,during cardiopulmonary bypasses at certain intervals and after the end of the cardiopulmonary artery bypass. Method of measurement: Arterial blood sample and arterial gas analyzer.;PH Level. Timepoint: Before starting of cardiopulmonary bypass and during anesthesia,During cardiopulmonary bypasses at certain intervals and after the end of the cardiopulmonary artery bypass. Method of measurement: Arterial blood sample and arterial gas analyzer.;Duration of mechanical ventilation after surgery in patients. Timepoint: After surgery and in the intensive care unit. Method of measurement: The length of time the patient is in the intensive care unit is connected to the ventilator.;The duration of return of normal heart rhythm and the need for defibrillator and the need to use pacemakers. Timepoint: After surgery and in the intensive care unit. Method of measurement: Within 48 hours after the end of the pulmonary bypass.	—

Measure

Time frame

Brain Oxygenation. Timepoint: 120, 150 and 180 seconds after injections of inotropic drugs during cardiopulmonary bypass. Method of measurement: Monitoring of cerebral oxygen saturation.;Blood lactate level. Timepoint: Before the starting of cardiopulmonary bypass and during anesthesia,during cardiopulmonary bypasses at certain intervals and after the end of the cardiopulmonary artery bypass. Method of measurement: Arterial blood sample and arterial gas analyzer.;PH Level. Timepoint: Before starting of cardiopulmonary bypass and during anesthesia,During cardiopulmonary bypasses at certain intervals and after the end of the cardiopulmonary artery bypass. Method of measurement: Arterial blood sample and arterial gas analyzer.;Duration of mechanical ventilation after surgery in patients. Timepoint: After surgery and in the intensive care unit. Method of measurement: The length of time the patient is in the intensive care unit is connected to the ventilator.;The duration of return of normal heart rhythm and the need for defibrillator and the need to use pacemakers. Timepoint: After surgery and in the intensive care unit. Method of measurement: Within 48 hours after the end of the pulmonary bypass.

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Secondary

Measure	Time frame
The rate of Use of Epinephrine, Norepinephrine and Phenylephrine for Maintaining Mean Arterial Pressure in the Range of 60 to 80 mmHg. Timepoint: At a time when the patient's blood pressure falls below 60 mm Hg during cardiopulmonary bypass. Method of measurement: Observation.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactReza Rostami

Shahid Rajaee Cardiovascular heart center

rostami_reza755@yahoo.com+98 21 6653 9401

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026