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the effect of ventilator settings on diaphragm atrophy

the effect of ventilator settings based on diaphragm thickening fraction on diaphragm atrophy

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
IRCT
Registry ID
IRCT20190510043545N3
Enrollment
40
Registered
2023-11-06
Start date
2023-11-21
Completion date
Unknown
Last updated
2023-11-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diaphragm atrophy. Mechanical complication of respirator

Interventions

Intervention 1: Intervention group: In the normal settings of the ventilator on pcv (pressure control ventilation) mode, the ventilator is set based on DTF. If the DTF (diaphragm thickening fraction)
Increased inspiratory pressure (settings tend to 8 cc/kg) and if the DTF is less than 15%, in the same range
Inspiratory pressure decreases. (settings tend to 6 cc/kg). Intervention 2: Control group: The control group uses the usual settings of the ventilator. In the usual settings of the ventilator in the P

Sponsors

Mashhad University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: Over 18 years with informed consent (from family) The patient has been intubated in the last 24 hours. be on (pressure controlled ventilator mode).

Exclusion criteria

Exclusion criteria: Absence of underlying diseases (like: lung disease, myopathy, brain disease, connective tissue disease) No poisoning with things that cause muscle paralysis.

Design outcomes

Primary

MeasureTime frame
Diaphragm Thickness. Timepoint: daily for 3 days. Method of measurement: Ultrasonography.

Secondary

MeasureTime frame
Diaphragm thickening fraction. Timepoint: Daily for 3 days. Method of measurement: Ultrasonography.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSeyed Javad Purafzali Firuzabadi

Mashhad University of Medical Sciences

sjvdpurafzali@yahoo.com+98 936 624 9277

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026