Induction of anesthesia with etomidate and propofol on surgical stress responses

Comparison of induction of anesthesia with etomidate and propofol on surgical stress responses in spinal elective surgery

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20190506043492N5

Enrollment

Registered

2020-07-07

Start date

2018-04-21

Completion date

Unknown

Last updated

2020-07-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Stress Rresponse. Other complications of anaesthesia

Interventions

Intervention 1: First Intervention group:In order to induce anesthesia, 0.3 mg / kg of atomidate (oxy-nac, Elixir Pharmaceuticals, Boroujerd, Iran) were injected intravenously. Intervention 2: Second

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Lack of severe bacterial or chronic viral infection Do not take antidepressants Lack of autoimmune diseases Lack of connective tissue disease Lack of liver and kidney disorders Lack of peripheral vascular disease, heart failure, thyroid disease Lack of mental disorders

Exclusion criteria

Exclusion criteria: Dissatisfaction with continuing to study

Design outcomes

Primary

Measure	Time frame
Serum level IL-1. Timepoint: Immediately before surgery and anesthesia, 24 hours, 48 hours and one week after surgery. Method of measurement: IL-1 blood serum levels in a blood biochemistry test.;Serum level IL-2. Timepoint: Immediately before surgery and anesthesia, 24 hours, 48 hours and one week after surgery. Method of measurement: Blood serum IL-2 levels in a blood biochemistry test.;Serum albumin levels. Timepoint: Immediately before surgery and anesthesia, 24 hours, 48 hours and one week after surgery. Method of measurement: Serum levels of blood albumin in a blood biochemistry test.;Serum glucose levels. Timepoint: Immediately before surgery and anesthesia, 24 hours, 48 hours and one week after surgery. Method of measurement: Serum blood glucose levels in a blood biochemistry test.;C-reactive-protein (Crp) Level. Timepoint: Immediately before surgery and anesthesia, 24 hours, 48 hours and one week after surgery. Method of measurement: Serum Crp blood levels in blood biochemistry tests.;Serum cortisol levels. Timepoint: Immediately before surgery and anesthesia, 24 hours, 48 hours and one week after surgery. Method of measurement: Serum levels of blood cortisol in a blood biochemistry test.	—

Measure

Time frame

Serum level IL-1. Timepoint: Immediately before surgery and anesthesia, 24 hours, 48 hours and one week after surgery. Method of measurement: IL-1 blood serum levels in a blood biochemistry test.;Serum level IL-2. Timepoint: Immediately before surgery and anesthesia, 24 hours, 48 hours and one week after surgery. Method of measurement: Blood serum IL-2 levels in a blood biochemistry test.;Serum albumin levels. Timepoint: Immediately before surgery and anesthesia, 24 hours, 48 hours and one week after surgery. Method of measurement: Serum levels of blood albumin in a blood biochemistry test.;Serum glucose levels. Timepoint: Immediately before surgery and anesthesia, 24 hours, 48 hours and one week after surgery. Method of measurement: Serum blood glucose levels in a blood biochemistry test.;C-reactive-protein (Crp) Level. Timepoint: Immediately before surgery and anesthesia, 24 hours, 48 hours and one week after surgery. Method of measurement: Serum Crp blood levels in blood biochemistry tests.;Serum cortisol levels. Timepoint: Immediately before surgery and anesthesia, 24 hours, 48 hours and one week after surgery. Method of measurement: Serum levels of blood cortisol in a blood biochemistry test.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohamad Mahdi Mina

Ahvaz University of Medical Sciences

Mahdi552m@hotmail.com+98 61 3373 8383

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026