Investigation of the effect of inhaled heparin in the treatment of patients with adult respiratory distress syndrome hospitalized in the intensive care unit

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20190506043492N4

Enrollment

Registered

2020-06-22

Start date

2020-04-08

Completion date

Unknown

Last updated

2020-07-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute respiratory distress syndrome. Acute respiratory distress syndrome

Interventions

Intervention 1: Intervention group: Patients in the intervention group In addition to routine care, 5,000 units are used every 12 hours for 7 days.The heparin used is 5,000 units produced by Iran Pakh

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Patients 18 to 60 years Under mechanical ventilation for more than 48 hours Respiratory index PAO2 / FIO2 =200 mmhg Bilateral pulmonary infiltration in the chest x-ray Lack of heart disease and previous lung disease Positive end expiratory pressure or PEEP= ventilator 5 cmh2 No history of intracerebral hemorrhage in the past 12 months No history of heparin-induced thrombocytopenia

Exclusion criteria

Exclusion criteria: Dissatisfaction to continue working on the study Hypersensitivity to heparin Uncontrolled bleeding or bleeding disorders PTT and INR impaired Patients receiving therapeutic doses of heparin, anaxaparin and warfarin

Design outcomes

Primary

Measure	Time frame
Respiratory index: PAO2 / FIO2. Timepoint: 1 to 7 days after the intervention. Method of measurement: Ventilator.;Arterial blood gas parameters. Timepoint: 1 to 7 days after the intervention. Method of measurement: ABG test.;The amount of PEEP required for effective mechanical ventilation. Timepoint: 1 to 7 days after the intervention. Method of measurement: Ventilator.;The time required for mechanical ventilation. Timepoint: 1 to 7 days after the intervention. Method of measurement: The number of days it has been subjected to mechanical ventilationnumber.;Mortality rate is 48 hours and 7 days. Timepoint: 1 to 7 days after the intervention. Method of measurement: Mortality rate.;Respiratory parameters. Timepoint: 1 to 7 days after the intervention. Method of measurement: Lung capacity? Tidal Volume, Respiratory rate, Minute Ventilation, Paco2.	—

Measure

Time frame

Respiratory index: PAO2 / FIO2. Timepoint: 1 to 7 days after the intervention. Method of measurement: Ventilator.;Arterial blood gas parameters. Timepoint: 1 to 7 days after the intervention. Method of measurement: ABG test.;The amount of PEEP required for effective mechanical ventilation. Timepoint: 1 to 7 days after the intervention. Method of measurement: Ventilator.;The time required for mechanical ventilation. Timepoint: 1 to 7 days after the intervention. Method of measurement: The number of days it has been subjected to mechanical ventilationnumber.;Mortality rate is 48 hours and 7 days. Timepoint: 1 to 7 days after the intervention. Method of measurement: Mortality rate.;Respiratory parameters. Timepoint: 1 to 7 days after the intervention. Method of measurement: Lung capacity? Tidal Volume, Respiratory rate, Minute Ventilation, Paco2.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactNastaran sadat Hoseini

Ahvaz University of Medical Sciences

Eglantin92@gmail.com+98 61 3373 8383

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026