The effect of N-acetyl cysteine on renal function after open heart surgery

Investigation of the effect of N-acetyl cysteine on renal function after coronary artery bypass graft surgery

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20190506043492N3

Enrollment

Registered

2020-06-07

Start date

2018-04-22

Completion date

Unknown

Last updated

2020-06-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

kidney disease. Hypertensive heart and chronic kidney disease

Interventions

Intervention 1: Intervention group: After induction of anesthesia and intubation, they will receive 150 mg / kg n-acetylcysteine intravenously (Oxy-Nak, Elixir Pharmacy, Boroujerd, Iran). Intervention

Eligibility

Sex/Gender

All

Age

30 Years to 70 Years

Inclusion criteria

Inclusion criteria: Candidates for open heart surgery. Be 30 to 70 years old. Have normal kidney and liver functionDo not have thyroid disease, hypertension, diabetes and arrhythmia. Don't be addicted to drugs. Glomerular filtration should be less than 60.

Exclusion criteria

Exclusion criteria: The patient is not satisfied to participate in the study. If the patient is taking renal effective drugs such as steroids and anti-inflammatory. If you are allergic to N-acetyl cysteine.

Design outcomes

Primary

Measure	Time frame
The effect of N-acetyl cysteine on renal factors after open heart surgery. Timepoint: Before anesthesia, 1,3,12, 24 and 48 hours later. Method of measurement: Serum level of creatinine in blood tests.;The effect of N-acetyl cysteine on renal factors after open heart surgery. Timepoint: Before anesthesia, 1,3,12, 24 and 48 hours later. Method of measurement: Serum level of BUN in blood tests.;The effect of N-acetyl cysteine on renal factors after open heart surgery. Timepoint: Before anesthesia, 1,3,12, 24 and 48 hours later. Method of measurement: Serum level of GFR in blood tests.;The effect of N-acetyl cysteine on renal factors after open heart surgery. Timepoint: Before anesthesia, 1,3,12, 24 and 48 hours later. Method of measurement: Urinary albumin levels.	—

Measure

Time frame

The effect of N-acetyl cysteine on renal factors after open heart surgery. Timepoint: Before anesthesia, 1,3,12, 24 and 48 hours later. Method of measurement: Serum level of creatinine in blood tests.;The effect of N-acetyl cysteine on renal factors after open heart surgery. Timepoint: Before anesthesia, 1,3,12, 24 and 48 hours later. Method of measurement: Serum level of BUN in blood tests.;The effect of N-acetyl cysteine on renal factors after open heart surgery. Timepoint: Before anesthesia, 1,3,12, 24 and 48 hours later. Method of measurement: Serum level of GFR in blood tests.;The effect of N-acetyl cysteine on renal factors after open heart surgery. Timepoint: Before anesthesia, 1,3,12, 24 and 48 hours later. Method of measurement: Urinary albumin levels.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactZahra shaker

Ahvaz University of Medical Sciences

shaker.z@ajums.ac.ir+98 61 3373 8383

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 22, 2026