the effect of N-acetyl cysteine on liver function after open heart surgery

Investigation of the effect of N-acetyl cysteine on liver function after open heart surgery

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20190506043492N2

Enrollment

Registered

2020-05-23

Start date

2018-04-21

Completion date

Unknown

Last updated

2020-06-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Liver diseas. Liver disease, unspecified

Interventions

Intervention 1: Intervention group: After induction of anesthesia and intubation, they will receive 150 mg / kg n-acetylcysteine intravenously (Oxy-Nak, Elixir Pharmacy, Boroujerd, Iran). Intervention

Eligibility

Sex/Gender

All

Age

30 Years to 70 Years

Inclusion criteria

Inclusion criteria: Entry Criteria: Candidates for open heart surgery Be 30 to 70 years old Have normal kidney and liver function Do not have thyroid disease, hypertension, diabetes and arrhythmia Don't be addicted to drugs.

Exclusion criteria

Exclusion criteria: Output criterion: The patient is not satisfied to participate in the study If the patient is taking effective drugs such as steroids, anti-inflammatory or anti fungal drugs If you are allergic to N-acetyl cysteine

Design outcomes

Primary

Measure	Time frame
The effect of N-acetyl cysteine on liver enzymes after open heart surgery. Timepoint: Before anesthesia, 1, 24 and 48 hours later. Method of measurement: Serum levels of alkaline phosphatase in blood tests.;The effect of N-acetyl cysteine on liver enzymes after open heart surgery. Timepoint: Before anesthesia, 1, 24 and 48 hours later. Method of measurement: Serum levels of Aspartate Aminotransferase Alanine in blood tests.;The effect of N-acetyl cysteine on liver enzymes after open heart surgery. Timepoint: Before anesthesia, 1, 24 and 48 hours later. Method of measurement: Serum levels of Aminotransferase in blood tests.;The effect of N-acetyl cysteine on liver enzymes after open heart surgery. Timepoint: Before anesthesia, 1, 24 and 48 hours later. Method of measurement: Serum levels of Gamma Glutamyl Transferase in blood tests.;The effect of N-acetyl cysteine on liver enzymes after open heart surgery. Timepoint: Before anesthesia, 1, 24 and 48 hours later. Method of measurement: Serum levels of Bilirubin in blood tests.	—

Measure

Time frame

The effect of N-acetyl cysteine on liver enzymes after open heart surgery. Timepoint: Before anesthesia, 1, 24 and 48 hours later. Method of measurement: Serum levels of alkaline phosphatase in blood tests.;The effect of N-acetyl cysteine on liver enzymes after open heart surgery. Timepoint: Before anesthesia, 1, 24 and 48 hours later. Method of measurement: Serum levels of Aspartate Aminotransferase Alanine in blood tests.;The effect of N-acetyl cysteine on liver enzymes after open heart surgery. Timepoint: Before anesthesia, 1, 24 and 48 hours later. Method of measurement: Serum levels of Aminotransferase in blood tests.;The effect of N-acetyl cysteine on liver enzymes after open heart surgery. Timepoint: Before anesthesia, 1, 24 and 48 hours later. Method of measurement: Serum levels of Gamma Glutamyl Transferase in blood tests.;The effect of N-acetyl cysteine on liver enzymes after open heart surgery. Timepoint: Before anesthesia, 1, 24 and 48 hours later. Method of measurement: Serum levels of Bilirubin in blood tests.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactPegah Abbasi Hirmozi

Ahvaz University of Medical Sciences

Shima.abbacihormozi@yahoo.com+98 61 3373 8383

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026