Comparison of the efficacy of oral Acetaminophen and intravenous Acetaminophen for closure of patent ductus arteriosus in preterm neonates

Comparison of the efficacy of oral Acetaminophen and intravenous Acetaminophen for closure of patent ductus arteriosus in preterm neonates admitted in neonatal intensive care unit of Akbar Abadi Hospital

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20190505043478N1

Enrollment

100

Registered

2019-05-10

Start date

2019-04-21

Completion date

Unknown

Last updated

2019-05-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patent ductus arteriosus (PDA). Patent ductus arteriosus

Interventions

Intervention 1: Intervention group 1: Includes premature neonates with PDA diagnosis by pediatric cardiologist. In this group, samples (n=50) received oral Acetaminophen at a dose of 15mg / kg every 6

Eligibility

Sex/Gender

All

Age

1 Days to 20 Days

Inclusion criteria

Inclusion criteria: Written parental consent is obtained Gestational age 26 to 37 weeks Diagnosis of ductus arteriosus based on echocardiographic evidence at 24 to 72 hours after birth

Exclusion criteria

Exclusion criteria: No Parental consent Any congenital heart disease with the need to PDA to keep blood flow constant ( Based on patient records). Life threatening infections .( Based on patient records) Liver Disease

Design outcomes

Primary

Measure	Time frame
PDA size. Timepoint: The neonates receives echocardiography before and after treatment. Method of measurement: Patient PDA evaluated before and after treatment, based on severity of the disease, and findings of the echocardiography by pediatiric's cardiologist .	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactShadi Adib

Iran University of Medical Sciences

shadiadib95@gmail.com+98 21 2304 6253

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026