Comparison of the effect of erythropoietin and ozone on joint function in patients with knee osteoarthritis

Comparison prolotherapy with erythropoietin and ozone with injections of sodium hyaluronate, chondroitin sulfate and ozone in reducing pain in patients with knee osteoarthritis

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20190503043450N1

Enrollment

100

Registered

2020-01-18

Start date

2019-05-22

Completion date

Unknown

Last updated

2020-02-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Knee osteoarthritis. Osteoarthritis, unspecified site

Interventions

Intervention 1: Intervention group 1: Erythropoietin injection twice with 3 weeks intervals with dose as 4000 International Units per milliliter made in Iran in Razavi pharmaceutical company in cooper

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Knee osteoarthritis Informed consent to participate in the study Complications of pain, crepitus and knee stiffness for at least three months Visual Analogue Scale score more than 3

Exclusion criteria

Exclusion criteria: infection Any knee injections in the last three months Diabetes mellitus History of rheumatoid arthritis Injection of steroid drugs over the past two months. Drug addiction Arthroplasty Body mass index more than 42 History of cancer Pregnancy Radiculopathy Neuropathy Anticoagulant use

Design outcomes

Primary

Measure	Time frame
Knee pain. Timepoint: Measurement of pain before injection and 3, 6, 9 and 12 months after injection. Method of measurement: With visual analogue scale.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAmirreza Alavi

Zahedan University of Medical Sciences

Amirrezaalavi@zaums.ac.ir+98 54 3329 5570

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026