Medical Treatment with Aloevera Gel in Chronic Anal Fissure

Comparison of Internal Sphincterotomy and Medical Treatment with Aloevera Gel in Chronic Anal Fissure

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20190430043425N1

Enrollment

Registered

2019-05-16

Start date

2019-05-22

Completion date

Unknown

Last updated

2019-08-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic anal fissure. Chronic anal fissure

Interventions

Intervention 1: Control group: Internal sphincterotomy. This method is an operation performed on the internal anal sphincter muscle. The procedure helps by lowering the resting pressure of the interna

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients with chronic fissure that require treatment.

Exclusion criteria

Exclusion criteria: Diabetes Crohn's disease Ulcerative colitis Cancer Pregnancy

Design outcomes

Primary

Measure	Time frame
Comparison of internal sphincterotomy and medical treatment with Aloevera gel in itching of chronic anal fissure. Timepoint: Two, four and six weeks after treatment. Method of measurement: The itching score is defined from 0 lack of itching up to 4 very severe itching.;Comparison of internal sphincterotomy and medical treatment with Aloevera gel in bleeding of chronic anal fissure. Timepoint: Two, four and six weeks after treatment. Method of measurement: Permanent bleeding after defication means high bleeding, bleeding occasionally during defication means middle bleeding and the presence of thin transparent blood without bleeding during defication means that the bleeding is low and the absence of bleeding, for at least 5 days, means no bleeding.;Comparison of internal sphincterotomy and medical treatment with Aloevera gel in the pain of chronic anal fissure. Timepoint: Two, four and six weeks after treatment. Method of measurement: The complete absence of pain means relief in pain and having any rate of pain means no relief in pain.;Comparison of internal sphincterotomy and medical treatment with Aloevera gel in wound healing of chronic anal fissure. Timepoint: Two, four and six weeks after treatment. Method of measurement: Full recovery of wound means anoderm healing without scarring and inflammation, relative healing of the wound means reducing inflammation and swelling of the wound, lack of wound healing means remaining the wound or worsening as abscess or fistula.	—

Measure

Time frame

Comparison of internal sphincterotomy and medical treatment with Aloevera gel in itching of chronic anal fissure. Timepoint: Two, four and six weeks after treatment. Method of measurement: The itching score is defined from 0 lack of itching up to 4 very severe itching.;Comparison of internal sphincterotomy and medical treatment with Aloevera gel in bleeding of chronic anal fissure. Timepoint: Two, four and six weeks after treatment. Method of measurement: Permanent bleeding after defication means high bleeding, bleeding occasionally during defication means middle bleeding and the presence of thin transparent blood without bleeding during defication means that the bleeding is low and the absence of bleeding, for at least 5 days, means no bleeding.;Comparison of internal sphincterotomy and medical treatment with Aloevera gel in the pain of chronic anal fissure. Timepoint: Two, four and six weeks after treatment. Method of measurement: The complete absence of pain means relief in pain and having any rate of pain means no relief in pain.;Comparison of internal sphincterotomy and medical treatment with Aloevera gel in wound healing of chronic anal fissure. Timepoint: Two, four and six weeks after treatment. Method of measurement: Full recovery of wound means anoderm healing without scarring and inflammation, relative healing of the wound means reducing inflammation and swelling of the wound, lack of wound healing means remaining the wound or worsening as abscess or fistula.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactDavoud Karimzadeh Aghda

Qazvin University of Medical Sciences

davoud.karim65@gmail.com+98 28 3333 6001

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026