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Comparison of the effect of oral gabapentin with a dose of intravenous acetaminophen on pain after knee arthroplasty

Comparison of the effect of oral gabapentin with a dose of intravenous acetaminophen on pain after knee arthroplasty

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20190430043424N1
Enrollment
15
Registered
2019-05-12
Start date
2019-04-17
Completion date
Unknown
Last updated
2019-05-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Knee arthroplasty. Unspecified complication of internal orthopaedic prosthetic device, implant and graft

Interventions

Intervention 1: Intervention group1: Infusion of 1000 milligrams of intravenous acetaminophen during the first half-hour during surgery. Intervention 2: Intervention group: assumption of 600 mg oral

Sponsors

Mashhad University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 75 Years

Inclusion criteria

Inclusion criteria: Physical grade I or II in ASA Lack of sensitivity to Gabapentin The absence of mental disorders Do not drink alcohol, drugs, and taking constipation, and corticosteroids and anticonvulsants on a regular basis or in the past twenty four hours No pregnancy No myasthenia grave disease Not having any kidney disease

Exclusion criteria

Exclusion criteria: The occurrence of any surgical complications during surgery Reduce or increase the average blood pressure (MAP) Heart rate is greater than 30% of the initial rate

Design outcomes

Primary

MeasureTime frame
Drug measurements. Timepoint: after intervention. Method of measurement: MORPHIN EQUIVALLENT.

Secondary

MeasureTime frame
Pain. Timepoint: after intervention. Method of measurement: Visual Analogue Scale.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohammad Alipour

Mashhad University of Medical Sciences

alipourm@mums.ac.ir+98 51 3852 5209

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026