Traumatic Brain Injury. Other specified intracranial injury with loss of consciousness of unspecified duration
Conditions
Interventions
Intervention 1: Intervention group: After 24 hours of brian injury 40000 unit of Erythropoietin Ampule via intravenous pathway is injected and patients receive 8000 unit of Erythropoietin intravenousl
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
15 Years to 65 Years
Inclusion criteria
Inclusion criteria: Range of Age between 15-65 years Traumatic Brain Injury(Epidural, Subdural, Intracranial, Intraventricular, Subarachnoid Hemorrhage, Diffuse Axonal Injury) Level of consciousness equal and less than 9 Hemoglobin less than 18 Mean Arterial Pressure less than 130 Onset of Brain Injury less than 24 hours Lack of History of Venous Thrombosis
Exclusion criteria
Exclusion criteria: Oragn Dysfunction(Uremic and Hepatic Encephalopathy) History of Malignancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Level of Consciousness. Timepoint: Evaluation of level of consciousness in initial of the study(before intervention) and daily until two weeks after Erythropoietin injection. Method of measurement: Glascow Coma Score, Four Score. | — |
Secondary
| Measure | Time frame |
|---|---|
| Time course for complete wakefullness after first Erythropoietin or Placebo injection. Timepoint: Daily until two weeks after Erythropoietin or Placebo injection. Method of measurement: Nursing Questionary.;Time course after Brain Injury until first Erythropoietin or Placebo injection. Timepoint: Onset of the study (before injection). Method of measurement: Nursing Questionary.;Time course for increasing in Glascow Coma Score and Four Score after first Erythropoietin or Placebo injection. Timepoint: Daily until two weeks after Erythropoietin or Placebo injection. Method of measurement: Nursing Questionary.;Incidense of Deep Vein Thrombosis. Timepoint: Daily from first Erythropoietin injection until last injection. Method of measurement: Physical Exam, Doppler Ultra Sonography of lower Extremity. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAtabak Najafi
Tehran University of Medical Sciences
Outcome results
None listed