Carpal tunnel syndrome. Carpal tunnel syndrome
Conditions
Interventions
Intervention 1: Intervention group: 1 mg clemastine tablet every night along with CTS night splint (Volar cockup wrist splint, Prefabricated) for three months. Intervention 2: Control group: Taking a
Sponsors
Iran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
20 Years to 60 Years
Inclusion criteria
Inclusion criteria: Pain or paresthesia or hypoesthesia in distal hand region or thenar weakness, with positive tinel or phalen tests No clinical evidence of cervical radiculopathy or radicular pain Negative history for Carpal Tunnel Release (CTR) surgery No injection inside or in proximity of carpal tunnel in last 3 months No present contraindication for Clemastine, such as drug allergy to antihistamine group Patient is willing to knowingly participate in a clinical trial
Exclusion criteria
Exclusion criteria: Patient isn't cooperative for questionnaire completion Drug or alcohol addiction Major depressive disorder or uncontrolled psychiatric disorders Positive history for malignancy or infection in wrist or hand region History of ischemic or neurovascular injury in wrist or hand region Usage of other treatment measures during trial period Patient doesn't follow correct treatment plan regarding drug or splint usage
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Patient's pain intensity(Visual Analogue Scale). Timepoint: Before, after one month and after three months of intervention. Method of measurement: Using the Visual Analogue Scale.;Median nerve sensory action potential amplitude. Timepoint: Before, after one month and after three months of intervention. Method of measurement: Nerve conduction study.;Median nerve sensory action potential latency. Timepoint: Before, after one month and after three months of intervention. Method of measurement: Nerve conduction study.;Median nerve motor action potential latency. Timepoint: Before, after one month and after three months of intervention. Method of measurement: Nerve conduction study.;Median nerve motor action potential amplitude. Timepoint: Before, after one month and after three months of intervention. Method of measurement: Nerve conduction study. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactGolam Reza Raissi
Iran University of Medical Sciences
Outcome results
None listed