Tranexamic Acid in Total Knee Arthroplasty

Comparison of the Effect of Intravenous Tranexamic Acid on Reducing Postoperative Bleeding Volume in Patients with Complete Replacement of Knee Joint

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20190427043390N1

Enrollment

Registered

2019-09-28

Start date

2016-09-22

Completion date

Unknown

Last updated

2019-11-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

primary osteoerthritis. Primary generalized (osteo)arthrosis

Interventions

Intervention 1: Intervention group: Intravenous injection of one gram of single dose tranexamic acid, during ten minutes before surgery. Intervention 2: Intervention group: Intervention group: intra-a

Eligibility

Sex/Gender

All

Age

50 Years to No maximum

Inclusion criteria

Inclusion criteria: All patients with knee articular cartilage destruction that do not respond to supportive treatments

Exclusion criteria

Exclusion criteria: revision

Design outcomes

Primary

Measure	Time frame
Average amount of blood lost. Timepoint: During and after surgery. Method of measurement: Graduated cylinders in milliliters.	—

Secondary

Measure	Time frame
Deep vein thrombosis , thromboembolism. Timepoint: during 3 month post-surgical. Method of measurement: physical examination.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAli torkaman

Iran University of Medical Sciences

Torkaman.a@iums.ac.ir+98 21 8214 1201

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026