Condition 1: Severity of tinnitus symptoms. Condition 2: Insomnia severity. Condition 3: Quality of Life. Tinnitus Insomnia
Conditions
Interventions
Intervention 1: Intervention group: 8 mg of Betahistine tablets plus Memantine tablets with instructions to take from the first to the seventh day: 5 mg
8th to 14th day: 5 mg twice a day
15th to 21st day: 5 mg in the morning and 10 mg in the evening
From the 22nd day to the 90th day, 10 mg twice a day. Intervention 2: 8 mg Betahistine tablets and placebo.
Sponsors
Zanjan University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: Having primary tinnitus for more than 3 months Willingness and interest to participate in the study Having moderate intensity of insomnia (scoring more than 15 based on the ISI Insomnia Severity Questionnaire)
Exclusion criteria
Exclusion criteria: Tinnitus due to anatomical disease tumor Previous use of memantine History of high blood pressure Suffering from chronic and debilitating diseases as diagnosed by the attending physician Known mental illness Concomitant use of medications that interact with memantine contraindication of memantine by the doctors diagnosis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Severity of tinnitus intensity. Timepoint: Before intervention and 3 months after the start of the intervention. Method of measurement: Tinnitus severity index standard questionnaire. | — |
Secondary
| Measure | Time frame |
|---|---|
| Insomnia severity. Timepoint: Before the start of the intervention and 3 months after the start of the intervention. Method of measurement: ISI Insomnia Severity Index Questionnaire.;Quality of Life. Timepoint: Before the start of the intervention and 3 months after the start of the intervention. Method of measurement: Standard Quality of Life Questionnaire (SF-36). | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr. Hamed Ghavimi
Zanjan University of Medical Sciences
Outcome results
None listed