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Evaluation of the therapeutic effects of livergol (silymarin) on the neuropathy caused by chemotherapy drugs.

Evaluation of the therapeutic effects of livergol (silymarin) on the neuropathy caused by chemotherapy drugs (cisplatin, oxaliplatin and paclitaxel) in patients admitted to Education & Treatment Center of Valiasr.

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
IRCT
Registry ID
IRCT20190427043389N3
Enrollment
70
Registered
2020-02-01
Start date
2020-02-20
Completion date
Unknown
Last updated
2020-02-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chemotherapy. Encounter for antineoplastic chemotherapy

Interventions

Intervention 1: Intervention group: received livergol tablet produced by Goldarou Co. (140 mg ) once a day for three months. Intervention 2: Control group: received placebo tablet produced by Goldaro

Sponsors

Zanjan University of Medical Sciences
Lead Sponsor
Goldaru Pharmaceutical Company
Collaborator

Eligibility

Sex/Gender
All
Age
35 Years to 75 Years

Inclusion criteria

Inclusion criteria: Age range 35-75 years Patients with cancers receiving oxaliplatin, cisplatin or paclitaxel-based chemotherapy regimens Patients with concussions admitted to Valiasr educational center or referred to Valiasr Oncology Clinic

Exclusion criteria

Exclusion criteria: Liverpool contraindication The presence of peripheral peripheral neuropathy continues to be the treatment that needs to be changed with chemotherapy regimens Other underlying etiologies of neuropathy

Design outcomes

Primary

MeasureTime frame
Evaluation of the effect of Levergol on the outcome of neuropathy in patients with concussion undergoing chemotherapy with oxaliplatin and paclitaxel. Timepoint: three months. Method of measurement: FACT/GOG-NTX.

Secondary

MeasureTime frame
Determination of quality of life in livergol recipient group. Timepoint: three months. Method of measurement: FACT/GOG-NTX.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Hamed Ghavimi

Zanjan University of Medical Sciences

Hamed.ghavimi@gmail.com+98 24 3347 3635

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026