The effect of pioglitazone on reducing opioid and heroin dependence.

The effect of adding pioglitazone to the regimen of opium-dependent & heroin-dependent patients on quality of life and treatment efficacy.

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20190427043389N2

Enrollment

100

Registered

2020-01-16

Start date

2019-11-15

Completion date

Unknown

Last updated

2020-02-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Opiate and heroin-dependent patients. Opioid abuse

Interventions

Intervention 1: Intervention group: received pioglitazone tablet (30 mg per day) for three months. Intervention 2: Control group: received placebo tablet for three months.

Eligibility

Sex/Gender

All

Age

20 Years to 50 Years

Inclusion criteria

Inclusion criteria: Opium and heroin-dependent patients admitted to Shahid Beheshti Hospital in Zanjan are included in the study. Opium and heroin-dependent patients referred to the clinic of beheshti training center of zanjan in the study. The age range of patients is between 20 to 50 years.

Exclusion criteria

Exclusion criteria: chronic medical conditions include diabetes , severe liver disorder & severe heart disorder. pioglitazone contraindications if any.

Design outcomes

Primary

Measure	Time frame
Evaluation of the effect of pioglitazone on treatment outcome in opium and heroin dependent patients. Timepoint: three months. Method of measurement: Based on the nottingham questionnaire.	—

Secondary

Measure	Time frame
Determination of quality of life in pioglitazone recipient group. Timepoint: three months. Method of measurement: Based on the nottingham questionnaire.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Hamed Ghavimi

Zanjan University of Medical Sciences

Hamed.ghavimi@gmail.com+98 24 3347 3635

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026