Effect of aerobic training and vitamin D supplementation on liver Fat, liver enzymes and lipid profile

Effect of aerobic training and vitamin D supplementation on liver Fat, liver enzymes and lipid profile in elderly women with nonalcoholic fatty liver and vitamin D deficiency

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

IRCT

Registry ID

IRCT20190423043359N1

Enrollment

Registered

2019-08-15

Start date

2018-12-12

Completion date

Unknown

Last updated

2019-10-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Non-alcoholic fatty liver disease. Fatty (change of) liver, not elsewhere classified

Interventions

Intervention 1: The aerobic training + vitamin D supplementation Intervention will be consists of 20-40 minutes of aerobic exercise at 60% - 75% of HRmax, 3 times a week for eight weeks and vitamin D

Eligibility

Sex/Gender

Female

Age

60 Years to 65 Years

Inclusion criteria

Inclusion criteria: Ultrasound (US) confirmation of being in second or third grade of NAFLD and certified by an internist 25-OHD serum levels between 10 and 20 ng/ml Being in second or third grade of NAFLD Not having a specific diet and regular exercise program in the past year

Exclusion criteria

Exclusion criteria: Significant consumption of alcohol more than 20 gr per day Presence of other liver diseases (B and C hepatitis) Other disorders such as autoimmune hepatitis, joint disease, celiac and Wilson disease, coronary artery disease, kidney failure, hypothyroidism Surgical treatment of obesity or severe weight loss Presence of any other chronic disease or skeletal disorders

Design outcomes

Primary

Measure	Time frame
Liver fat levels. Timepoint: Evaluation of fatty liver grade prior to the intervention and 24-48 h after intervention finished. Method of measurement: Using ultrasound (US).;Vitamin D levels. Timepoint: Prior to the beginning and at the end of the study. Method of measurement: By blood sampling.;Anthropometric indices. Timepoint: Before the study starts and after the study ends. Method of measurement: Using INBODY test.;Lipid profile. Timepoint: Before the study starts and after it ended. Method of measurement: Blood sampling.;Serum levels of liver enzymes. Timepoint: Before the study starts and after it ended. Method of measurement: Blood sampling.;Glucose and insulin levels. Timepoint: Before the study starts and after it ended. Method of measurement: Blood sampling.;Blood pressure. Timepoint: Before the study starts and after it ended. Method of measurement: Digital sphygmomanometer.	—

Measure

Time frame

Liver fat levels. Timepoint: Evaluation of fatty liver grade prior to the intervention and 24-48 h after intervention finished. Method of measurement: Using ultrasound (US).;Vitamin D levels. Timepoint: Prior to the beginning and at the end of the study. Method of measurement: By blood sampling.;Anthropometric indices. Timepoint: Before the study starts and after the study ends. Method of measurement: Using INBODY test.;Lipid profile. Timepoint: Before the study starts and after it ended. Method of measurement: Blood sampling.;Serum levels of liver enzymes. Timepoint: Before the study starts and after it ended. Method of measurement: Blood sampling.;Glucose and insulin levels. Timepoint: Before the study starts and after it ended. Method of measurement: Blood sampling.;Blood pressure. Timepoint: Before the study starts and after it ended. Method of measurement: Digital sphygmomanometer.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactRastegar Hoseini

Razi University

Rastegar.hoseini@gmail.com+98 83 3428 3272

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026