The effect of Melatonin on Delirium Prevention

Comparing melatonin and placebo in prevention of postoprative delirium after orthopedic surgery under spinal anesthesia in the elderly.

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20190419043320N1

Enrollment

Registered

2019-05-20

Start date

2019-05-28

Completion date

Unknown

Last updated

2019-08-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Delirium. Other delirium

Interventions

Intervention group: One melatonin 5-milligram capsule

night before surgery and the night of surgery and two nights later (one capsule every night).

Eligibility

Sex/Gender

All

Age

60 Years to No maximum

Inclusion criteria

Inclusion criteria: All patients over the age of 60 under hip, femure or knee surgery Surgery under spinal anesthesia

Exclusion criteria

Exclusion criteria: Drug abuse Dementia Sensory loss including blindness and deafness Epilepsy

Design outcomes

Primary

Measure	Time frame
Delirium. Timepoint: At the beginning of the study and T the first, second and third days after the intervention. Method of measurement: MMT Test Questionnaire.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactHamid Reza Banafshe

Kashan University of Medical Sciences

banafshe_h@kaums.ac.ir+98 31 5554 0021

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026