osteoarthritis. Primary osteoarthritis of other joints
Conditions
Interventions
Intervention 1: Intervention group: Acetaminophen tablet 4 times a day plus NSAIDs with one glass of water (one of the following NSAIDs will be considered: 1200mg Ibuprofen, 75mg Indomethacin, 500mg
Sponsors
Bojnourd University of Medical Sciences
Eligibility
Sex/Gender
All
Age
40 Years to No maximum
Inclusion criteria
Inclusion criteria: 1) aged over 40 years 2) Primary osteoarthritis 3) Pain in more than half the days of the previous month during one of the following activities: walking, climbing and stairs, standing up or sleeping on the bed or mattress during the night 4) Radiographic evidence of tibiafemoral or patellofemoral osteoarthritis 5) A score of 40 from the WOMAC scale as a base 6) No intra-articular injection of hyaluronic acid / glucocorticoid over the last six months 7) The lack of a positive pregnancy test or pregnancy program during the study
Exclusion criteria
Exclusion criteria: 1) intolerance to the drug 2) Do not take medicine properly 3) Serious medical conditions that the patient can not regularly attend periodic visits include severe cardiovascular disease such as angina or heart attack, severe hypertension, recent stroke, insulin dependent diabetes, psychiatric disorders, kidney disease, liver disease, active concen , And anemia 4) history of liver disease 5) Inability to walk without a cane 6) A history of autoimmune diseases such as rheumatoid arthritis 7) Secondary osteoarthritis, for example, following a trauma
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Joint range of movement. Timepoint: Weeks 1,2,3,7,16. Method of measurement: Clinical examination.;Pain. Timepoint: Weeks 1,2,3,7,16. Method of measurement: VAS, KOOS and WOMAC questionnaire. | — |
Secondary
| Measure | Time frame |
|---|---|
| Change in serum levels of inflammatory mediators (IL-1? INF-?). Timepoint: Weeks of 1 and 16. Method of measurement: ELISA Kits.;Change in serum levels of inflammatory and anti-inflammatory mediators(IL-10). Timepoint: Weeks of 1 and 16. Method of measurement: ELISA Kits. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAdeleh Sahebnasagh
Bojnourd University of Medical Sciences
Outcome results
None listed