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Investigating the effect of whole body vibration on serum levels of blood factors and ankle muscle strength in people with diabetic peripheral neuropathy

Evaluation of the Effect of Whole Body Vibration on the Circulated Nitric Oxide, Vascular Endothelium Growth Factor and Ankle Muscles Strength in People with Diabetic Peripheral Neuropathy

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
IRCT
Registry ID
IRCT20190417043299N4
Enrollment
18
Registered
2025-01-17
Start date
2025-02-19
Completion date
Unknown
Last updated
2025-02-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diabetic peripheral neuropathy. Diabetes mellitus due to underlying condition with diabetic neuropathy, unspecified

Interventions

Intervention 1: Intervention group: Individuals in this group will perform isometric squat training with a whole-body vibration machine for 24 sessions (8 weeks). Each session will consist of 10 one-m

Sponsors

Tabriz University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
50 Years to 70 Years

Inclusion criteria

Inclusion criteria: Type 2 diabetic patients with peripheral neuropathy 25 < body mass index < 35 Hb A1C less than 8.5% Mild to moderate neuropathy (score 29-7) based on the Michigan questionnaire People who are able to stand on both legs

Exclusion criteria

Exclusion criteria: Contraindications of whole body vibration Patients with non-diabetic neuropathy Presence of a wound in the leg Taking drugs and supplements that have known effects on the central nervous system, peripheral and blood vessels Patients with venous thrombosis Having other complications of diabetes such as nephropathy, retinopathy and cardiovascular problems Have a history of using a whole body vibration device before Participation in other research studies Unwillingness to continue cooperation

Design outcomes

Primary

MeasureTime frame
Changes in the plasma nitric oxide level before and after exercises. Timepoint: Before and after the first and twenty-fourth training sessions. Method of measurement: By blood test.;Changes in plasma levels of vascular endothelial growth factor before and after exercise. Timepoint: Before and after the first and twenty-fourth training sessions. Method of measurement: By blood test.;Changes in ankle muscle strength. Timepoint: Before the first sessions and after the twenty-fourth training session. Method of measurement: by dynamometer.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSeyed Ahmad Bagherian

Tabriz University of Medical Sciences

a.bagherian@modares.ac.ir+98 41 3337 3207

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026