Evaluation of effect of trifolium plant on hypothyroidism

Evaluation of effect of hydroalcoholic extract of trifolium plant in patients with subclinical hypothyroidism

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20190415043279N3

Enrollment

Registered

2020-05-24

Start date

2020-01-21

Completion date

Unknown

Last updated

2025-12-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Subclinical hypothyroidism. Subclinical iodine-deficiency hypothyroidism

Interventions

Intervention 1: Intervention group: Capsule containing hydroalcoholic extract of trifolium plant at a dose of 500 mg per day for three consecutive months. These oral capsules of trifolium plant are pr

Eligibility

Sex/Gender

All

Age

18 Years to 70 Years

Inclusion criteria

Inclusion criteria: Patients with lately diagnosed subclinical hypothyroidism

Exclusion criteria

Exclusion criteria: Thyroiditis Pregnancy Cardiovascular disease Thyroid cancer Recent surgery Blood disorders children Breastfeeding chronic Diseases Dissatisfaction patients to participate in the study

Design outcomes

Primary

Measure	Time frame
Serum TSH levels. Timepoint: Measurement of TSH levels before the intervention and three months later. Method of measurement: Serum level evaluation.;Serum T4 levels. Timepoint: Measurement of T4 levels before the intervention and three months later. Method of measurement: Serum level evaluation.;Serum T3 levels. Timepoint: Measurement of T3 levels before the intervention and three months later. Method of measurement: Serum level evaluation.	—

Measure

Time frame

Serum TSH levels. Timepoint: Measurement of TSH levels before the intervention and three months later. Method of measurement: Serum level evaluation.;Serum T4 levels. Timepoint: Measurement of T4 levels before the intervention and three months later. Method of measurement: Serum level evaluation.;Serum T3 levels. Timepoint: Measurement of T3 levels before the intervention and three months later. Method of measurement: Serum level evaluation.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactShahnaz Ghafouri

Sanandaj University of Medical Sciences

drghafoorish76@gmail.com+98 87 3366 4645

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026