Diltiazem in fissure

comparison of the effectiveness topical diltiazem and nefidipin in improving symptom and healing in patient with acute fissure

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

IRCT

Registry ID

IRCT20190414043275N1

Enrollment

140

Registered

2021-07-05

Start date

2021-07-22

Completion date

Unknown

Last updated

2021-07-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute anal fissure. Acute anal fissure

Interventions

Intervention 1: Group-A will received 0.3% nifedipine ointment, Synthesized in the pharmacy of Razi Hospital affiliated to Tehran University of Medical Sciences, Peri-anally , three times a day, qua

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Acute fissure

Exclusion criteria

Exclusion criteria: Pregnancy history of anal surgery Anorectal malformation

Design outcomes

Primary

Measure	Time frame
Duration of pain. Timepoint: Before the intervention, every week for up to 8 weeks after the intervention. Method of measurement: Question from the patient.	—

Secondary

Measure	Time frame
Healing of anal fissure. Timepoint: After two months of intervention. Method of measurement: Physical examination.;Relapse. Timepoint: 6 months after intervention. Method of measurement: Question from the patient.	—

Countries

Iran (Islamic Republic of)

Contacts

Public Contactzahra momayez sanat

Tehran University of Medical Sciences

msanat67@gmail.com+98 21 84901

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026