Comparison of the oocyte quality in patients with poor ovarian response undergone two triggering methods.

Comparison of two methods of double- trigger (GNRHa+HCG) and HCG-trigger on the final oocyte maturation in poor responder patients.

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20190409043207N2

Enrollment

122

Registered

2019-10-22

Start date

2019-09-06

Completion date

Unknown

Last updated

2021-08-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Infertility. Complication associated with artificial fertilization, unspecified

Interventions

Intervention 1: Intervention group: Intervention group: Trigger with 0.2 mg deca peptil ampoule and 10000 HCG ampoule 40 and 34 hours before oocyte retrieval. Intervention 2: Intervention group: Trigg

Eligibility

Sex/Gender

Female

Age

18 Years to 50 Years

Inclusion criteria

Inclusion criteria: Age more than 40 years or other risk factors for poor ovarian response. Less than three oocytes in the previous IVF cycle Abnormal ovarian reserve test Two histories of poor ovarian response following receiving maximal stimulation

Exclusion criteria

Exclusion criteria: Severe male factor Untreated endocrine disorders Severe uterine anomaly

Design outcomes

Primary

Measure	Time frame
Clinical pregnancy rate. Timepoint: Four weeks after positive beta hCG. Method of measurement: Fetal heart activity by trans-vaginal ultrasonography.	—

Secondary

Measure	Time frame
Biochemical pregnancy rate. Timepoint: 14 days after embryo transfer. Method of measurement: Positive B-HCG.;Implantation rate. Timepoint: 4 weeks after embryo transfer. Method of measurement: It is defined as the numbers of gestational sacs that detected throughout sonography per number of embryos transferred (100 embryo).;Abortion rate. Timepoint: Before 20th weeks of gestation. Method of measurement: Observation and counting.;COC counting. Timepoint: The day of oocyte puncture. Method of measurement: Counting.;MII oocyte number. Timepoint: The day of puncture. Method of measurement: Counting.;2PN number. Timepoint: 1 day after fertilization. Method of measurement: Counting.;Estradiol level. Timepoint: In the day of hCG injection. Method of measurement: Biochemical measurements in the blood.;Embryo grading. Timepoint: 3 days after puncture. Method of measurement: Observation and grading according to the embryo references.	—

Measure

Time frame

Biochemical pregnancy rate. Timepoint: 14 days after embryo transfer. Method of measurement: Positive B-HCG.;Implantation rate. Timepoint: 4 weeks after embryo transfer. Method of measurement: It is defined as the numbers of gestational sacs that detected throughout sonography per number of embryos transferred (100 embryo).;Abortion rate. Timepoint: Before 20th weeks of gestation. Method of measurement: Observation and counting.;COC counting. Timepoint: The day of oocyte puncture. Method of measurement: Counting.;MII oocyte number. Timepoint: The day of puncture. Method of measurement: Counting.;2PN number. Timepoint: 1 day after fertilization. Method of measurement: Counting.;Estradiol level. Timepoint: In the day of hCG injection. Method of measurement: Biochemical measurements in the blood.;Embryo grading. Timepoint: 3 days after puncture. Method of measurement: Observation and grading according to the embryo references.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr maryam Mortazavi

Yazd University of Medical Sciences

m_mortazavi58@yahoo.com+98 35 3824 8119

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026