Arthritis rheumatoid. Rheumatoid arthritis, unspecified
Conditions
Interventions
Intervention 1: Intervention group: Propolis supplement (Propolis supplement capsule containing 500 mg of propolis, Shahdineh Golha Pharmaceutical Company, 2 times a day, daily consumption for 3 month
Sponsors
Mashhad University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
20 Years to 70 Years
Inclusion criteria
Inclusion criteria: People in the age range of 20-70 years Patients with moderate and severe disease activity score 28 Do not take antioxidant supplements for at least 1 month before starting the study The tendency to cooperate and sign informed written consent Diagnosis of the disease by a rheumatologist based on the criteria of the American College of Rheumatology
Exclusion criteria
Exclusion criteria: Pregnancy and lactation Taking oral contraceptive pills History of chronic diseases such as diabetes mellitus, kidney failure, liver failure and cancer Having other autoimmune and inflammatory diseases Having Hormonal disorders, thyroid disorders Alcohol consumption and hookah smoke Smoking and being exposed to secondhand smoke
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Total antioxidant capacity. Timepoint: Before and after of intervention. Method of measurement: Elisa kit.;Interleukin 17. Timepoint: Before and after of intervention. Method of measurement: Elisa kit.;Total oxidant status. Timepoint: Before and after of intervention. Method of measurement: Elisa kit.;Tumor necrosis factor alpha. Timepoint: Before and after of intervention. Method of measurement: Elisa kit.;Malondialdehyde. Timepoint: Before and after of intervention. Method of measurement: Elisa kit.;Glutathione peroxidase. Timepoint: Before and after of intervention. Method of measurement: Elisa kit.;Catalase. Timepoint: Before and after of intervention. Method of measurement: Elisa kit.;Superoxide dismutase. Timepoint: Before and after of intervention. Method of measurement: Elisa kit.;Triglyceride. Timepoint: Before and after of intervention. Method of measurement: Laboratory test.;Low density lipoprotein. Timepoint: Before and after of intervention. Method of measurement: Laboratory test.;High density lipoprotein. Timepoint: Before and after of intervention. Method of measurement: Laboratory test.;Blood pressure. Timepoint: Before and after of intervention. Method of measurement: Mercury barometer.;Dietary intake. Timepoint: Before and after of intervention. Method of measurement: Three days food record.;Physical activity. Timepoint: Before and after of intervention. Method of measurement: International Physical Activity Questionnaire.;Anthropometric measurements. Timepoint: Before and after of intervention. Method of measurement: Body mass index, waist circumference, Hip circumference.;High sensivity C-reactive protein. Timepoint: Before and after of intervention. Method of measurement: Elisa kit.;Monocyte Chemoattractant Protein-1. Timepoint: Before and after of intervention. Method of measurement: Elisa kit.;Nitric oxide. Timepoint: Before and after of intervention. Method of measurement: Elisa kit. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMaryam Khosravi
Mashhad University of Medical Sciences
Outcome results
None listed