Knee osteoarthritis.
Conditions
Interventions
Intervention 1: Intervention group: Sesame oil soft capsule three times a day, and routine treatment with meloxicam tablets. Intervention 2: Control group: Placebo capsule three times a day, and routi
Sponsors
Mashhad University of Medical Sciences
Eligibility
Sex/Gender
All
Age
40 Years to 80 Years
Inclusion criteria
Inclusion criteria: Primary symptomatic osteoarthritis in at least one knee confirmed by clinical or radiological criteria (American College of Rheumatology (ACR) criteria). No adequate response to medical treatment (Meloxicam) after at least two weeks of administration before the start of the study. A baseline visual analog scale (VAS) score higher than 30 at the beginning of the study.
Exclusion criteria
Exclusion criteria: The intra-articular injection of hyaluronic acid in the three months before the start of the study The 4-week treatment with oral corticosteroids before the start of the study Patients with a history of deep vein thrombosis Active liver or renal disease and malignancies Secondary osteoarthritis or suspected Patients treated with hormonal drugs Patients treated with anticoagulation drugs Patients with a history of ischemic or hemorrhagic stroke
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain. Timepoint: Early intervention, four weeks after the intervention, eight weeks after intervention. Method of measurement: Western Ontario and McMasters Universities Osteoarthritis Index (Womac) questionnaire and Visual Analog Scale (VAS).;Joint stiffness. Timepoint: Early intervention, four weeks after the intervention, eight weeks after intervention. Method of measurement: Western Ontario and McMaster Universities Arthritis Index (WOMAC)questionnaire and Visual Analog Scale (VAS).;Physical performance. Timepoint: Early intervention, four weeks after the intervention, eight weeks after intervention. Method of measurement: Western Ontario and McMaster Universities Arthritis Index (WOMAC)questionnaire and Visual Analog Scale (VAS). | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactFatemeh Forouzanfar
Mashhad University of Medical Sciences
Outcome results
None listed