Knee osteoarthritis.
Conditions
Interventions
Intervention 1: Intervention group: Portulaca oleracea capsule (prepared in Pharmacological Research Center of Medicinal Plants) three times a day, and routine treatment with meloxicam tablets. Interv
Sponsors
Mashhad University of Medical Sciences
Eligibility
Sex/Gender
All
Age
40 Years to 80 Years
Inclusion criteria
Inclusion criteria: Initial symptomatic osteoarthritis in at least one knee by clinical or radiological criteria ACR (American College of Rheumatology) is approved Lack of proper adherence to routine drug treatment (meloxicam tablets) for at least two weeks before the study Score higher than 30 at baseline VAS scale
Exclusion criteria
Exclusion criteria: The intra-articular injection of hyaluronic acid in the three months before the start of the study The 4-week treatment with oral corticosteroids before the start of the study Patients with a history of deep vein thrombosis Active liver or renal disease and malignancies Secondary osteoarthritis or suspected Patients treated with hormonal drugs Patients treated with anticoagulation drugs Patients with a history of ischemic or hemorrhagic stroke
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain. Timepoint: Early intervention, four weeks after the intervention, eight weeks after intervention. Method of measurement: Western Ontario and McMasters Universities Osteoarthritis Index (Womac) questionnaire and Visual Analog Scale (VAS) scale.;Joint stiffness. Timepoint: Early intervention, four weeks after the intervention, eight weeks after intervention. Method of measurement: (Womac) questionnaire and (VAS) scale.;Physical performance. Timepoint: Early intervention, four weeks after the intervention, eight weeks after intervention. Method of measurement: (Womac) questionnaire and (VAS) scale. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactFatemeh Forouzanfar
Mashhad University of Medical Sciences
Outcome results
None listed