Persimmon and Nigella sativa toothpaste for treating gingivitis

Investigating the effectiveness of toothpaste containing persimmon and Nigella sativa in the treatment of patients with gingivitis

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20190406043175N13

Enrollment

Registered

2025-07-17

Start date

2025-09-22

Completion date

Unknown

Last updated

2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gingivitis. Chronic gingivitis

Interventions

Intervention 1: Intervention group: Toothpaste containing extract of persimmon and nigella sativa. For each patient, toothpaste of persimmon extract two times a day for 4 weeks is administered. Herbal

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Gingivitis patients

Exclusion criteria

Exclusion criteria: Pregnant or lactating women Allergic to oral hygiene products

Design outcomes

Primary

Measure	Time frame
Gingivitis index. Timepoint: At baseline and week 4 of the trial. Method of measurement: Examination by periodontist with periodontal Williams probe.;Plaque index. Timepoint: At baseline, and week 4 of the trial. Method of measurement: Examination by periodontist with periodontal Williams probe.;Bleeding on probing. Timepoint: At baseline and week 4 of the trial. Method of measurement: Examination by periodontist with periodontal Williams probe.	—

Measure

Time frame

Gingivitis index. Timepoint: At baseline and week 4 of the trial. Method of measurement: Examination by periodontist with periodontal Williams probe.;Plaque index. Timepoint: At baseline, and week 4 of the trial. Method of measurement: Examination by periodontist with periodontal Williams probe.;Bleeding on probing. Timepoint: At baseline and week 4 of the trial. Method of measurement: Examination by periodontist with periodontal Williams probe.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactFatemeh Forouzanfar

Mashhad University of Medical Sciences

forouzanfarf@mums.ac.ir+98 51 3800 2538

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026