Comparison of the effect of TDCS and RTMS in the treatment of migraine

Evaluation of the effectiveness of treatment with Trans cranial direct current stimulation in comparison with Repetitive Trans cranial Magnetic Stimulation in improving pain, anxiety, depression and quality of life in patients with migraine

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20190404043159N4

Enrollment

Registered

2021-10-09

Start date

2021-10-23

Completion date

Unknown

Last updated

2021-11-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Migraine. Migraine

Interventions

Intervention 1: Intervention group: Patients with migraine will be treated with electrical stimulation by the TDCS method with a intensity of 2 mA in the Dorsolateral Prefrontal cortex, in twelve sess

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: All 18 to 60 years old migraine patients with the code (ICHS-II 1.2.1) according to the International Classification of Headache Disorders (2004) and with a history of migraine attacks (of any severity) during a recent year that is confirmed by a neurologist. Conscious consent to participate in the study Have a minimum literacy

Exclusion criteria

Exclusion criteria: A serious suicide plan or thoughts Pregnancy or Breastfeeding Substance abuse A history of seizures or any neurological disease (other than Migraine) Having a Pacemaker or any metal Implants in the upper limbs or head and neck History of any brain stimulation such as ECT(Electroconvulsive therapy) 7. History of taking antidepressants and anti-anxiety drugs from two months before entering the study Depressive, Bipolar, or Psychotic disorders based on DSM-V (Diagnostic and Statistical Manual of Mental Disorders ) Criteria during examination by a Psychiatrist and Psychiatric Assistant

Design outcomes

Primary

Measure	Time frame
Pain intensity based on Visual Analogue Scale (VAS). Timepoint: At the beginning of the study and one month after the intervention. Method of measurement: Pain intensity based on Visual Analogue Scale (VAS).;Depression score. Timepoint: At the beginning of the study and one month after the intervention. Method of measurement: Based on the Hospital Anxiety and Depression Scale (HADS).;Anxiety score. Timepoint: At the beginning of the study and one month after the intervention. Method of measurement: Based on the Hospital Anxiety and Depression Scale (HADS).;Quality of life score. Timepoint: At the beginning of the study and one month after the intervention. Method of measurement: Based on the Headache Impact Test (HIT) questionnaire.	—

Measure

Time frame

Pain intensity based on Visual Analogue Scale (VAS). Timepoint: At the beginning of the study and one month after the intervention. Method of measurement: Pain intensity based on Visual Analogue Scale (VAS).;Depression score. Timepoint: At the beginning of the study and one month after the intervention. Method of measurement: Based on the Hospital Anxiety and Depression Scale (HADS).;Anxiety score. Timepoint: At the beginning of the study and one month after the intervention. Method of measurement: Based on the Hospital Anxiety and Depression Scale (HADS).;Quality of life score. Timepoint: At the beginning of the study and one month after the intervention. Method of measurement: Based on the Headache Impact Test (HIT) questionnaire.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohammad Reza Sharbafchi

Esfahan University of Medical Sciences

sharbafchi@med.mui.ac.ir+98 31 3668 0042

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026