Effect of Ondansetron on block of spinal anesthesia

Effect of preoperative intravenous Ondansetron on level and time to regression of sensory and motor block in patients undergoing cesarean section during spinal anesthesia

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20190327043122N1

Enrollment

160

Registered

2020-03-03

Start date

2019-11-22

Completion date

Unknown

Last updated

2020-03-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Effect of ondansetron on level and time to regression of sensory and motor block in spinal anesthesia. Complications of anesthesia during labor and delivery

Interventions

Intervention 1: Intervention group: 4 miligrames(2cc) ondansetron (IV),15 minutes before spinal anesthesia with 2.5 cc hyperbaric bupivacaine is administered. In the event of a hypotension and brad

Eligibility

Sex/Gender

Female

Age

18 Years to 45 Years

Inclusion criteria

Inclusion criteria: women who candidate for cesarean section without any hearing problems , without neurologic disorders or use of alfa 2 agonists or calcium channel blockers in the last month Have not contraindication criteria for spinal anesthesia Have not history of long QT in the patient and family.

Exclusion criteria

Exclusion criteria: need to general anesthesia

Design outcomes

Primary

Measure	Time frame
Level and time to regression of sensory block in spinal anesthesia. Timepoint: Every 2 minutes after spinal anesthesia until fixation of sensory level then every 30 minutes till regression of block to the level of S1. Method of measurement: blunt niddle.;Time to reverse of motor block in spinal anesthesia. Timepoint: Every 30 minutes till regression of motor block. Method of measurement: Table of Modified Bromage scale.	—

Measure

Time frame

Level and time to regression of sensory block in spinal anesthesia. Timepoint: Every 2 minutes after spinal anesthesia until fixation of sensory level then every 30 minutes till regression of block to the level of S1. Method of measurement: blunt niddle.;Time to reverse of motor block in spinal anesthesia. Timepoint: Every 30 minutes till regression of motor block. Method of measurement: Table of Modified Bromage scale.

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Secondary

Measure	Time frame
Systolic blood pressure(SBP). Timepoint: Before and immediately after spinal anesthesia and every 3 minutes untill 30 minutes then every 5 minutes untill the end of surgery. Method of measurement: Sphygmomanometer.;Diastolic blood pressure(DBP). Timepoint: Before and immediately after spinal anesthesia and every 3 minutes untill 30 minutes then every 5 minutes untill the end of surgery. Method of measurement: Sphygmomanometer.;Mean arterial pressure(MAP). Timepoint: Before and immediately after spinal anesthesia and every 3 minutes untill 30 minutes then every 5 minutes untill the end of surgery. Method of measurement: Sphygmomanometer.;Heart rate(HR). Timepoint: Before and immediately after spinal anesthesia and every 3 minutes untill 30 minutes then every 5 minutes untill the end of surgery. Method of measurement: Cardiac monitoring(5 leads).;Pulse oximetry (SpO2). Timepoint: Before and immediately after spinal anesthesia and every 3 minutes untill 30 minutes then every 5 minutes untill the end of surgery. Method of measurement: pulse oximetry.	—

Measure

Time frame

Systolic blood pressure(SBP). Timepoint: Before and immediately after spinal anesthesia and every 3 minutes untill 30 minutes then every 5 minutes untill the end of surgery. Method of measurement: Sphygmomanometer.;Diastolic blood pressure(DBP). Timepoint: Before and immediately after spinal anesthesia and every 3 minutes untill 30 minutes then every 5 minutes untill the end of surgery. Method of measurement: Sphygmomanometer.;Mean arterial pressure(MAP). Timepoint: Before and immediately after spinal anesthesia and every 3 minutes untill 30 minutes then every 5 minutes untill the end of surgery. Method of measurement: Sphygmomanometer.;Heart rate(HR). Timepoint: Before and immediately after spinal anesthesia and every 3 minutes untill 30 minutes then every 5 minutes untill the end of surgery. Method of measurement: Cardiac monitoring(5 leads).;Pulse oximetry (SpO2). Timepoint: Before and immediately after spinal anesthesia and every 3 minutes untill 30 minutes then every 5 minutes untill the end of surgery. Method of measurement: pulse oximetry.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactSaleheh Asghari

Mashhad University of Medical Sciences

asgharisa@mums.ac.ir+98 51 3840 0000

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026