The effect of hypertonic saline on managing decompensated heart failure in patients with inadequate response to intravenous furosemide.

The impact of hypertonic saline solutions on the management of decompensated heart failure in patients exhibiting suboptimal therapeutic response to intravenous furosemide.

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20190325043107N76

Enrollment

Registered

2026-05-18

Start date

2026-06-04

Completion date

Unknown

Last updated

2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Heart Failure. Heart failure

Interventions

Intervention 1: Intervention group: Patients will receive 100 mg of intravenous furosemide plus 150 mL of 3% hypertonic saline over 30 minutes. Intervention 2: Control group: Patients will receive 100

Eligibility

Sex/Gender

All

Age

18 Years to 70 Years

Inclusion criteria

Inclusion criteria: Confirmed diagnosis of decompensated heart failure Orthopnea or paroxysmal nocturnal dyspnea (PND)

Exclusion criteria

Exclusion criteria: Cardiogenic shock Severe hyponatremia

Design outcomes

Primary

Measure	Time frame
Diuresis. Timepoint: Assessments are performed at three time points: baseline, 24 hours after initiation of furosemide, and 24 hours after the hypertonic saline intervention. Method of measurement: Measurement of urine output.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohammadreza Taban

Tabriz University of Medical Sciences

Mkhanbabayi@yahoo.com+98 41 3335 7310

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Jun 11, 2026