Effectiveness of Vitamin C in Laparoscopic Cholecystectomy

Comparison of the efficacy of intravenous vitamin C Versus placebo in the prevention of post-laparoscopic cholecystectomy shoulder pain syndrome

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20190325043107N73

Enrollment

Registered

2026-01-10

Start date

2026-01-31

Completion date

Unknown

Last updated

2026-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative shoulder pain. Pain in shoulder

Interventions

Intervention 1: Intervention group: The intervention group will receive 500 mg of vitamin C diluted in 50 mL of isotonic normal saline, administered as an intravenous infusion over 10 minutes twice da

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Patients with American Society of Anesthesiologists (ASA) physical status class I or II Surgical duration between 90 and 120 minutes

Exclusion criteria

Exclusion criteria: Use of vitamin C for more than one month Preoperative chronic shoulder pain

Design outcomes

Primary

Measure	Time frame
Postoperative shoulder pain. Timepoint: Immediately, two weeks, and four weeks after surgery. Method of measurement: Visual analog scale.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMehdi Khanbabayi Gol

Tabriz University of Medical Sciences

Khanbabayimehdi69@gmail.com+98 41 3334 7054

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 7, 2026