Comparison of Dexmedetomidine and Propofol on Acute Pain after Total Knee Arthroplasty under Spinal Anesthesia

Comparison of the Effects of Intraoperative Dexmedetomidine versus Propofol Infusion on Acute Postoperative Pain in Total Knee Arthroplasty under Spinal Anesthesia

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20190325043107N72

Enrollment

Registered

2025-12-26

Start date

2026-01-01

Completion date

Unknown

Last updated

2026-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative pain. Acute pain due to trauma

Interventions

Intervention 1: Intervention group: In the Dexmedetomidine group, intravenous Dexmedetomidine will be infused at an initial dose of 1 µg/kg (manufactured by Exir Pharmaceutical) over 10 minutes, follo

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: ASA Class I or II Candidates for elective unilateral knee arthroplasty Spinal anesthesia was performed for surgery

Exclusion criteria

Exclusion criteria: Patients with any contraindication to spinal anesthesia Hypersensitivity to Dexmedetomidine or Propofol

Design outcomes

Primary

Measure	Time frame
Postoperative pain. Timepoint: During the first 24 hours, at two-hour intervals. Method of measurement: Visual Analog Scale.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMehdi Khanbabayi Gol

Tabriz University of Medical Sciences

Khanbabayimehdi69@gmail.com+98 41 3334 7054

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 7, 2026