Dexmedetomidine and Hemodynamic Changes in Obese Patients

Effects of Adding a Low Dose of Dexmedetomidine to Anesthetic Premedication on Hemodynamic Changes During Intubation and Extubation in Obese Patients Undergoing Orthopedic Surgery

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20190325043107N68

Enrollment

120

Registered

2025-12-01

Start date

2025-12-20

Completion date

Unknown

Last updated

2025-12-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hemodynamic Changes. Encounter for examination of blood pressure without abnormal findings

Interventions

Intervention 1: Intervention group: For patients in the intervention group (those scheduled for orthopedic surgery), dexmedetomidine at a dose of 0.25 µg/kg will be administered prior to induction of

Eligibility

Sex/Gender

All

Age

45 Years to 65 Years

Inclusion criteria

Inclusion criteria: American Society of Anesthesiologists (ASA) physical status class I or II Age between 45 and 65 years Body mass index (BMI) between 35 and 40 Requirement for general anesthesia with endotracheal intubation

Exclusion criteria

Exclusion criteria: Body mass index (BMI) greater than 40 Patients with hemodynamic instability Patients with advanced cardiovascular diseases Patients with known hypersensitivity or allergy to the study drug

Design outcomes

Primary

Measure	Time frame
Hemodynamic Changes. Timepoint: Every three minutes for a duration of three hours. Method of measurement: Hemodynamic monitoring.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMehdi Khanbabayi Gol

Tabriz University of Medical Sciences

Khanbabayimehdi69@gmail.com+98 41 3334 7054

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026