Preventive analgesia with methylprednisolone beta with and without gabapentin in elderly patients undergoing total knee arthroplasty

The comparison of preventive analgesia with methylprednisolone plus gabapentin versus methylprednisolone alone in elderly patients undergoing total knee arthroplasty

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20190325043107N64

Enrollment

140

Registered

2025-10-20

Start date

2024-06-23

Completion date

Unknown

Last updated

2025-12-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative pain. Acute pain due to trauma

Interventions

Intervention 1: Intervention group 1: Thirty minutes before transfer to the operating room, patients will receive a 300-mg oral gabapentin tablet with 50 mL of water, followed by intravenous administr

Eligibility

Sex/Gender

All

Age

60 Years to 80 Years

Inclusion criteria

Inclusion criteria: Over 60 years of age ASA class I or II Candidate for elective unilateral total knee arthroplasty

Exclusion criteria

Exclusion criteria: Patients with any contraindication to spinal anesthesia Prior use of corticosteroid medications

Design outcomes

Primary

Measure	Time frame
Postoperative pain. Timepoint: Every two hours for 24 hours. Method of measurement: Visual Analog Scale (VAS).	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMehdi Khanbabayi Gol

Tabriz University of Medical Sciences

Khanbabayimehdi69@gmail.com+98 41 3334 7054

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026