Effect of Low-Dose Naloxone Added to Analgesia Pump in Total Knee Arthroplasty

Outcomes of Adding a Low Dose of Naloxone to Continuous Analgesia Pumps in Patients Undergoing Total Knee Arthroplasty

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20190325043107N62

Enrollment

Registered

2025-10-04

Start date

2024-05-19

Completion date

Unknown

Last updated

2025-10-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative pain. Acute pain due to trauma

Interventions

Intervention 1: Intervention group: At the end of surgery, patients in the intervention group received an intravenous analgesia pump containing morphine (20 µg/kg), dexamethasone (16 mg), fentanyl (20

Eligibility

Sex/Gender

All

Age

45 Years to 65 Years

Inclusion criteria

Inclusion criteria: Patients aged at least 45 years Patients who are candidates for total knee arthroplasty

Exclusion criteria

Exclusion criteria: Patients with a history of using opioid-containing analgesics Patients with a history of cardiovascular disorders Patients with a history of diabetes and neuropathy

Design outcomes

Primary

Measure	Time frame
Postoperative pain. Timepoint: Every two hours for 24 hours. Method of measurement: Visual Analog Scale (VAS).	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMehdi Khanbabayi Gol

Tabriz University of Medical Sciences

Khanbabayimehdi69@gmail.com+98 41 3334 7054

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026