Comparison of the effect of adding dexmedetomidine, fentanyl, magnesium sulfate to bupivacaine

Comparison of the effect of adding dexmedetomidine, fentanyl and magnesium sulfate to bupivacaine in the management of acute pain after knee replacement surgery.

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20190325043107N58

Enrollment

120

Registered

2025-08-02

Start date

2023-10-31

Completion date

Unknown

Last updated

2025-08-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pain Intensity. Acute pain due to trauma

Interventions

Intervention 1: Intervention group 1: In Group 1, patients will receive 20 mg of bupivacaine solution combined with 25 micrograms of sterile fentanyl, and their postoperative pain intensity will be as

Eligibility

Sex/Gender

All

Age

18 Years to 70 Years

Inclusion criteria

Inclusion criteria: ASA class I or II Scheduled for unilateral total knee arthroplasty Procedure performed by a single surgeon

Exclusion criteria

Exclusion criteria: Contraindications to spinal anesthesia Patients with hypersensitivity to any of the study medications Patients with a blood pressure greater than 160 mmHg

Design outcomes

Primary

Measure	Time frame
Pain Intensity. Timepoint: They will be measured at 1, 2, 4, 6, 12, 18, and 24 hours after surgery. Method of measurement: The Visual Analog Scale (VAS) was used to assess pain.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMehdi Khanbabayi Gol

Tabriz University of Medical Sciences

Khanbabayimehdi69@gmail.com+98 41 3334 7054

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Sep 9, 2026