Myasthenia gravis. Myasthenia gravis
Conditions
Interventions
Intervention group: Rituximab
Patients will be treated with rituximab. It will be given as one gram in the first week, one gram in the third week, and then one gram in the sixth month intravenousy (in normal saline solution)..
Sponsors
Esfahan University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: The patient has myasthenia gravis disease (positive AB test for AChR and MUSK *, evidence of myasthenia gravis disease in RNS test, positive Edrophonium test in the patient, and Chest MDCT for thymus involvement). * in Double Seronegative patients, both of these antibodies are negative; Therefore, the other 3 criteria used for diagnosis. In the patients positive for Anti AchR or negative for both antibodies, these characteristics must present: resistance to corticosteroid therapy or is contraindication; resistance to azathioprine treatment or its side effects occur which necessitate the discontinuation of the drug. In the patients positive for Anti MUSK, resistance to corticosteroid therapy or is contraindication, must occur. The patient doesn't have Eaton Lambert syndrome. The patient doesn't administrate unconventional medications (herbal, acupuncture, and etc.). Desire of the patient to participate in this study and Signing Written Informed Consent.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Quality of patient's life. Timepoint: At the time of enrolling the patient to study, and then every 3 moths in the following period of 1 year. Method of measurement: MGQOL15.;Signs and symptoms of myasthenia gravis. Timepoint: At the time of enrolling the patient to study, and then every 3 moths in the following period of 1 year. Method of measurement: MG Composite Scale.;Post-intervention Status of the patients. Timepoint: after 6 and 12 months after the beginning of study. Method of measurement: MGFA Post-intervention Status.;Clinical status of the patients. Timepoint: At the time of enrolling the patient to study, and then every 3 moths in the following period of 1 year. Method of measurement: MGFA Clinical Classification Scale.;Amount of daily activities in myasthenia gravis patients. Timepoint: At the time of enrolling the patient to study, and then every 3 moths in the following period of 1 year. Method of measurement: MG-ADL scale. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMahshid Golagha
Esfahan University of Medical Sciences
Outcome results
None listed