Major Depressive Disorder. Mood disorder due to known physiological condition with major depressive-like episode
Conditions
Interventions
Intervention 1: Intervention group: Ketamine with a dose of 0.75-0.50 mg/kg as a 40-minute infusion. Intervention 2: Control group: 0.9% saline as a 40-minute infusion.
Sponsors
Babol University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: having a major depressive episode based on a clinical interview (based on DSM-5) A total score of more than 5 on the Beck suicidal ideation scale A score of 14 or higher in the Beck depression questionnaire Absence of pregnancy or lactation Absence of obvious cognitive impairment or mental retardation
Exclusion criteria
Exclusion criteria: Receiving psychiatric medications within a month before starting ketamine treatment History of sensitivity to ketamine
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Suicidal Ideation. Timepoint: 48 hours after receiving the infusion. Method of measurement: Beck scale suicide ideation questionaire. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactFarzan Kheirkhah
Babol University of Medical Sciences
Outcome results
None listed