Condition 1: Human immunodeficiency virus [HIV] disease. Condition 2: depressive disorder. Condition 3: Insomnia. Human immunodeficiency virus [HIV] disease Major depressive disorder, single episode Insomnia not due to a substance or known physiological condition
Conditions
Interventions
Intervention 1: Intervention group: lactobacillus acidophilus capsule twice per day 10 exponent 8 unit daily for 12 weeks. Intervention 2: Control group: Starch placebo tablets exactly the same with
Sponsors
Karaj University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Over 18 years of age IQ above 70 No consumption of alcohol, drugs and stimulants in the last three months based on the result of the urine test CD4 level above 350 in the last three months HIV-positive patients are outpatients and not hospitalized and in controlled physical conditions with the approval of an infectious disease specialist Voluntary willingness of the individual to participate in the plan
Exclusion criteria
Exclusion criteria: prominent neurological or organic disease and cardiovascular disease and history of cardiac surgery or any cardiovascular procedure clinical and laboratory examinations and family history Another diagnosis in Axis I based on DSM-V abusing of other substances (except nicotine and caffeine) taking oral antipsychotics in the past week or long-acting antipsychotics in the past month receiving ECT in the last two weeks women of childbearing age will not be accepted without adequate methods of contraception CHF and liver disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Anxiety. Timepoint: At the beginning of the study, 4th ,8th ,and 12th weeks. Method of measurement: The Beck Anxiety Inventory (BAI).;Anorexia. Timepoint: At the beginning of the study, 4th ,8th ,and 12th weeks. Method of measurement: Simple appetite questionnaire.;Sleep quality. Timepoint: At the beginning of the study, 4th ,8th ,and 12th weeks. Method of measurement: Pittsburgh Sleep Quality Index (PSQI).;Cognitive impairment. Timepoint: At the beginning of the study, 4th ,8th ,and 12th weeks. Method of measurement: Montreal cognitive assessment(MoCA). | — |
Secondary
| Measure | Time frame |
|---|---|
| Mild gastrointestinal discomfort. Timepoint: At the beginning of this study, 4th ,8th and 12th weeks. Method of measurement: Medical history. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAtefe Zandifar
Karaj University of Medical Sciences
Outcome results
None listed