The effect of selenium, vitamin C and methylprednisolone combination on mortality and morbidity of Covid-19 patients.

The effect of combination of selenium, vitamin C and methylprednisolone in acute respiratory distress syndrome mortality and morbidity from COVID-19

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20190312043030N2

Enrollment

Registered

2020-08-19

Start date

2020-06-29

Completion date

Unknown

Last updated

2020-09-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

COVID-19. COVID-19

Interventions

Intervention 1: Control group:This group undergoing only routine treatments of the intensive care unit will be provided according to the national protocol that include tablet hydroxychloroquine and ta

Eligibility

Sex/Gender

All

Age

18 Years to 90 Years

Inclusion criteria

Inclusion criteria: Positive PCR test for Covid 19 Diffuse asymmetric pulmonary involvement on CT scan complies with Covid-19 Absence of evidence of liquid overload. PaO2/FiO2 ratio =300 and >200 is mild ARDS; PaO2/FiO2 ratio100-200 is moderate ARDS; PaO2/FiO2 ratio <100 is severe ARDS new/worsening respiratory symptoms within 1 week

Exclusion criteria

Exclusion criteria: Corticosteroid history over the past 3 months Sensitivity to vitamin C. Increased sensitivity to selenium. Primary creatinine above 1.5. Ethylene glycol poisoning.

Design outcomes

Primary

Measure	Time frame
Days of hospitalization in ICU. Timepoint: From the time of the patient's arrival until the diagnosis of ICU. Method of measurement: According to the number of days the patient was hospitalized in the ICU.;Mortality. Timepoint: From the beginning of the interventions to 5 days after the end of the interventions. Method of measurement: Mortality census based on patients recorded information.;Duration of mechanical ventilation. Timepoint: From the time the patient enters the ICU until discharge from this ward. Method of measurement: Number of days the patient is under mechanical ventilation based on patients recorded information.;Days of hospitalization. Timepoint: From initial admission to hospital discharge. Method of measurement: Number of days of patient attendance from initial admission to hospital discharge based on patients recorded information.	—

Measure

Time frame

Days of hospitalization in ICU. Timepoint: From the time of the patient's arrival until the diagnosis of ICU. Method of measurement: According to the number of days the patient was hospitalized in the ICU.;Mortality. Timepoint: From the beginning of the interventions to 5 days after the end of the interventions. Method of measurement: Mortality census based on patients recorded information.;Duration of mechanical ventilation. Timepoint: From the time the patient enters the ICU until discharge from this ward. Method of measurement: Number of days the patient is under mechanical ventilation based on patients recorded information.;Days of hospitalization. Timepoint: From initial admission to hospital discharge. Method of measurement: Number of days of patient attendance from initial admission to hospital discharge based on patients recorded information.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr.Seied Hadi Saghaleini

Tabriz University of Medical Sciences

hsaghaleini@gmail.com+98 41 3541 2101

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026