Effect of 17 a-Hydroxyprogesterone caproate on prevention of preterm labor.

A clinical trial to comparison the effectiveness of 17 a-Hydroxyprogesterone caproate with routine prenatal care on prevention of preterm labor in patients with a history of preterm labor.

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20190309042978N2

Enrollment

100

Registered

2019-03-19

Start date

2019-03-21

Completion date

Unknown

Last updated

2019-03-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Preterm labor. Preterm labour and delivery

Interventions

Intervention 1: Intervention group: The intervention group will receive 250 mg intra-muscular 17 a-Hydroxyprogesterone caproate at 16 weeks of gestation up to 37 weeks of gestation every week. Interve

Eligibility

Sex/Gender

Female

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Age higher than 18 years History of preterm labor

Exclusion criteria

Exclusion criteria: Active labor phase Premature rupture of the fetal membranes Preeclampsia Vaginal bleeding Dilation greater than 3cm and cervical length less than 25mm Intra-amniotic infection Using tocolytic drugs Allergic to progesterone

Design outcomes

Primary

Measure	Time frame
The mean gestational age at birth. Timepoint: After intervention. Method of measurement: Based on the first day of the last menstruation period or ultrasound.;Prevalence of preterm labor. Timepoint: After intervention. Method of measurement: Questionnaire.	—

Secondary

Measure	Time frame
The mean neonatal birth weigh. Timepoint: After intervention. Method of measurement: Scale.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactHamed Jafarpour

Sari University of Medical Sciences

h.jafarpour@mazums.ac.ir+98 11 3336 1700

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026