Effect of acetaminophen prophylaxis on ductus arteriosus closure in premature infants

Study the effect of acetaminophen prophylaxis on ductus arteriosus closure in premature infants under 31 weeks

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20190305042935N1

Enrollment

Registered

2019-03-14

Start date

2019-02-20

Completion date

Unknown

Last updated

2019-03-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Delayed closure of ductus arteriosus. Persistent fetal circulation

Interventions

Intervention 1: Intervention group: This group will receive acetaminophen prophylaxis 10 mg/ kg body weight, every 6 hours for 5 days as drops. Intervention 2: Control group: This group will not recei

Eligibility

Sex/Gender

All

Age

No minimum to 210 Days

Inclusion criteria

Inclusion criteria: Premature infants admitted to the neonatal intensive care unit Weight under 1500 grams Age under 31 weeks

Exclusion criteria

Exclusion criteria: Infants with congenital heart defects, congenital major abnormalities or chromosomal abnormalities Infants whose mothers have a history of using nonsteroidal anti-inflammatory drugs during pregnancy Infants with hydrops fetalis Infants with Apgar scores greater than 5 at five minutes after birth Infants with symptomatic PDA require treatment with ibuprofen Infants have vomiting or hematems in the first three days of birth Infants with high levels of liver enzymes

Design outcomes

Primary

Measure	Time frame
Ductus arteriosus status. Timepoint: Ten and thirty days after intervention. Method of measurement: Echocardiography.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDoctor Nabiollah Asadpour

Shahre-kord University of Medical Sciences

n.asadpour@skums.ac.ir+98 38 3333 5653

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026