Obesity. Obesity due to excess calories
Conditions
Interventions
Intervention 1: Intervention group: one butyrate capsule of 600mg/day(made by Body Bio company, USA, containing 550 mg of butyrate and 50 mg sodium hydroxide, medium-chain triglycerides (MCT), hydroxy
Sponsors
Tabriz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: Body mass index (BMI) between 30-40 Both of genders female and male Age between 18-60 years old
Exclusion criteria
Exclusion criteria: Unwillingness to participate in the study Kidney diseases liver failure heart failure rheumatic diseases diabetes malignancies, and gastrointestinal diseases Taking weightloss drugs and following a weight loss diet History of bariatric surgery Smoking Pregnancy, lactation, menopause
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Gene expression level of AdipoR1& R2. Timepoint: Before the intervention and two months after the intervention. Method of measurement: Real- time PCR.;Gene expression level of AMPK. Timepoint: Before the intervention and two months after the intervention. Method of measurement: Real- time PCR.;Gene expression level of UCP 2 & 3. Timepoint: Before the intervention and two months after the intervention. Method of measurement: Real- time PCR. | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum levels of hsCRP. Timepoint: Before the intervention and two months after the intervention. Method of measurement: ELISA kit.;Atherogenic index of plasma(AIP). Timepoint: Before the intervention and two months after the intervention. Method of measurement: based on formula: AIP=log??triglycerides /high density lipoprotein?. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactParichehr Amiri
Ahvaz University of Medical Sciences
Outcome results
None listed