Obesity. Obesity due to excess calories
Conditions
Interventions
Intervention 1: Intervention group: one butyrate capsule of 600mg/day (made by Body Bio company, USA, containing 550 mg of butyrate and 50 mg sodium hydroxide, medium-chain triglycerides (MCT), hydrox
Sponsors
Ahvaz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: Body mass index (BMI) between 30-40 Both of genders female and male Age between 18-60 years old
Exclusion criteria
Exclusion criteria: Unwillingness to participate in the study Kidney diseases, liver failure, heart failure, rheumatic diseases, diabetes, malignancies, and gastrointestinal diseases Consumption of any product or supplement containing probiotics, prebiotics and antibiotics in the last 1 month Taking vitamin, fiber, omega-3, antioxidant supplements during the 3 weeks before and during the study Taking weight-loss drugs and following a weight loss diet for the past six months History of bariatric surgery Smoking Pregnancy, lactation, menopause
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Weight. Timepoint: Before the intervention and two months after the intervention. Method of measurement: Using scales.;Waist circumference. Timepoint: Before the intervention and two months after the intervention. Method of measurement: Using tape.;Body mass index(BMI). Timepoint: Before the intervention and two months after the intervention. Method of measurement: By dividing weight (kg) to height square (m2).;Waist to hip ratio(WHR). Timepoint: Before the intervention and two months after the intervention. Method of measurement: Waist circumference/hip circumference.;Fat mass(FM). Timepoint: Before the intervention and two months after the intervention. Method of measurement: Using bioelectrical impedence analyser.;Fat free mass(FFM). Timepoint: Before the intervention and two months after the intervention. Method of measurement: Using bioelectrical impedence analyser.;Serum level of GLP-1. Timepoint: Before the intervention and two months after the intervention. Method of measurement: Enzyme-linked immunosorbent assay (ELISA) kit.;Gene expression of PGC-1a. Timepoint: Before the intervention and two months after the intervention. Method of measurement: Real time- PCR.;Gene expression of PPARa. Timepoint: Before the intervention and two months after the intervention. Method of measurement: Real time- PCR.;Gene expression of UCP1. Timepoint: Before the intervention and two months after the intervention. Method of measurement: Real time- PCR.;Serum level of LBP. Timepoint: Before the intervention and two months after the intervention. Method of measurement: Enzyme-linked immunosorbent assay (ELISA) kit.;Gene expression of TNF-a. Timepoint: Before the intervention and two months after the intervention. Method of measurement: Real time- PCR.;Gene expression of TLR4. Timepoint: Before the intervention and two months after the intervention. Method of measurement: Real time- PCR.;Gene expression of NFkB. Timepoint: Before the intervention and two months after the inter | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum levels of Triglyceride. Timepoint: Before the intervention and two months after the intervention. Method of measurement: Using enzymatic kit method.;Serum levels of High-Density Lipoprotein cholesterol (HDL-c). Timepoint: Before the intervention and two months after the intervention. Method of measurement: Using enzymatic kit method.;Serum levels of High-Density Lipoprotein cholesterol (LDL-c). Timepoint: Before the intervention and two months after the intervention. Method of measurement: Using enzymatic kit method.;Fasting blood sugar. Timepoint: Before the intervention and two months after the intervention. Method of measurement: Using enzymatic kit method.;Serum levels of alanine transaminase (ALT). Timepoint: Before the intervention and two months after the intervention. Method of measurement: Using enzymatic kit method.;Serum levels of aspartate aminotransferase (AST). Timepoint: Before the intervention and two months after the intervention. Method of measurement: Using enzymatic kit method.;Serum levels of insulin. Timepoint: Before the intervention and two months after the intervention. Method of measurement: Enzyme-linked immunosorbent assay (ELISA) kit. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactParichehr Amiri
Ahvaz University of Medical Sciences
Outcome results
None listed