Patients with Breast Cancer. Breast, unspecified
Conditions
Interventions
Intervention 1: Intervention group: Patients in the intervention group receiving oral quercetin supplementation. Oral supplementation Quercetin (pure America manufacturer) continues 2 weeks before sta
Sponsors
Rasht University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
1360 Years to 1360 Years
Inclusion criteria
Inclusion criteria: Eligible patients include women aged 21-69 years with sinus rhythm and normal ventricular drainage fraction, normal liver and kidney function, and normal hematology.Previously don`t have any document for chemotherapy or radiotherapy for other types of malignancies. They don`t have CHF. Have not experienced myocardial infarction. Do not suffer from obstruction or heart valves stenosis. They don`t have specific disease or specific drug therapy that affects cardiac function. EF do not have less than 55%.They don`t have cardiovascular disease risk factors , such as hypertension, high fat, and do not include smokers. Women in this clinical trial study are not pregnant and don`t have systolic pressure of less than 90 mmHg.
Exclusion criteria
Exclusion criteria: Unwillingness to appear in the plan, to make any changes to the treatment or use of the drug. At any time from the implementation of the plan, in the event of any unwanted side effects, the oral supplement will be discontinued and the patient will be excluded from the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The cardiac toxicity of doxorubicin is a primary outcome. Timepoint: The amount of troponin is measured one month after the start of chemotherapy and the end of the course. Method of measurement: Troponin test. | — |
Secondary
| Measure | Time frame |
|---|---|
| Quercetin cardiovascular effect is a secondary consequence. Timepoint: Echocardiography will be done at the end of the chemotherapy (first 3 months), 6 months later and one year later. Method of measurement: Echocardiography. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMona Hadad Zahmatkesh
Rasht University of Medical Sciences
Outcome results
None listed